Difference between revisions of "Propofol"

Propofol
Trade names	Diprivan
	Clinical data
Drug class	Sedative hypnotic
Uses	Induction and maintenance of anesthesia, sedation
Contraindications	Egg/soy allergy (controversial)
Routes of administration	Intravenous
Dosage	Induction of anesthesia: Adult: 1-2.5 mg/kg; Elderly: 1-1.5 mg/kg; Pediatric: 2.5-3.5 mg/kg; Maintenance of anesthesia: Adult: 100-200 mcg/kg/min; Elderly: 50-100 mcg/kg/min; Pediatric: 125-300 mcg/kg/min;
	Pharmacodynamics
Mechanism of action	GABA agonism
Adverse effects	Hypotension, bradycardia, pain on injection
	Pharmacokinetics
Onset of action	15-30 seconds
Duration of action	5-10 minutes
Metabolism	Liver glucuronidation
Redistribution half-life	2-8 minutes (initial) 30-70 minutes (slow)
Elimination half-life	1.5-31 hours
Clearance	1.5-2.2 L/min
	Physical and chemical data
	Article information
Editor rating	Unrated
Likes	0
	Top authors
	Chris Rishel, Barrett Larson and Test User 6

Revision as of 01:54, 3 February 2021

Provide a brief summary of this drug here.

@@ Line 19: / Line 19: @@
 | adverse_effects = Hypotension, bradycardia, pain on injection
 | time_onset = 15-30 seconds
+| duration = 5-10 minutes
+| metabolism = Liver glucuronidation
+| halflife_redistribution = 2-8 minutes (initial)
+-70 minutes (slow)
+| halflife_elimination = 1.5-31 hours
+| clearance = 1.5-2.2 L/min
 }}Provide a brief summary of this drug here.