Difference between revisions of "MediaWiki:Gadget-calculator-drugs-core.js"

Revision as of 16:17, 12 August 2021

/**
 * @author Chris Rishel
 */
( function() {
    var DEFAULT_DRUG_COLOR = 'default';
    var DEFAULT_DRUG_POPULATION = 'general';
    var DEFAULT_DRUG_ROUTE = 'iv';

    mw.calculators.isValueDependent = function( value, variableId ) {
        // This may need generalized to support other variables in the future
        if( variableId === 'weight' ) {
            return value && value.formatUnits().match( /\/[\s(]*?kg/ );
        } else {
            throw new Error( 'Dependence "' + variableId + '" not supported by isValueDependent' );
        }
    };

    /**
     * Define units
     */
    mw.calculators.addUnitsBases( {
        concentration: {
            toString: function( units ) {
                units = units.replace( ' pct', '%' );
                units = units.replace( 'ug', 'mcg' );

                return units;
            }
        },
        mass: {
            toString: function( units ) {
                units = units.replace( 'ug', 'mcg' );

                return units;
            }
        }
    } );

    mw.calculators.addUnits( {
        pct: {
            baseName: 'concentration',
            definition: '10 mg/mL'
        },
        vial: {
            baseName: 'volume'
        }
    } );



    /**
     * DrugColor
     */
    mw.calculators.drugColors = {};

    mw.calculators.addDrugColors = function( drugColorData ) {
        var drugColors = mw.calculators.createCalculatorObjects( 'DrugColor', drugColorData );

        for( var drugColorId in drugColors ) {
            mw.calculators.drugColors[ drugColorId ] = drugColors[ drugColorId ];
        }
    };

    mw.calculators.getDrugColor = function( drugColorId ) {
        if( mw.calculators.drugColors.hasOwnProperty( drugColorId ) ) {
            return mw.calculators.drugColors[ drugColorId ];
        } else {
            return null;
        }
    };

    /**
     * Class DrugColor
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugColor}
     * @constructor
     */
    mw.calculators.objectClasses.DrugColor = function( propertyValues ) {
        var properties = {
            required: [
                'id'
            ],
            optional: [
                'parentColor',
                'primaryColor',
                'highlightColor',
                'striped'
            ]
        };

        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );

        this.parentColor = this.parentColor || this.id === DEFAULT_DRUG_COLOR ? this.parentColor : DEFAULT_DRUG_COLOR;
    };

    mw.calculators.objectClasses.DrugColor.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );

    mw.calculators.objectClasses.DrugColor.prototype.getParentDrugColor = function() {
        if( !this.parentColor ) {
            return null;
        }

        var parentDrugColor = mw.calculators.getDrugColor( this.parentColor );

        if( !parentDrugColor ) {
            throw new Error( 'Parent drug color "' + this.parentColor + '" not found for drug color "' + this.id + '"' );
        }

        return parentDrugColor;
    };

    mw.calculators.objectClasses.DrugColor.prototype.getHighlightColor = function() {
        if( this.highlightColor ) {
            return this.highlightColor;
        } else if( this.parentColor ) {
            return this.getParentDrugColor().getHighlightColor();
        }
    };

    mw.calculators.objectClasses.DrugColor.prototype.getPrimaryColor = function() {
        if( this.primaryColor ) {
            return this.primaryColor;
        } else if( this.parentColor ) {
            return this.getParentDrugColor().getPrimaryColor();
        }
    };

    mw.calculators.objectClasses.DrugColor.prototype.isStriped = function() {
        if( this.striped !== null ) {
            return this.striped;
        } else if( this.parentColor ) {
            return this.getParentDrugColor().isStriped();
        }
    };





    /**
     * DrugPopulation
     */

    mw.calculators.drugPopulations = {};

    mw.calculators.addDrugPopulations = function( drugPopulationData ) {
        var drugPopulations = mw.calculators.createCalculatorObjects( 'DrugPopulation', drugPopulationData );

        for( var drugPopulationId in drugPopulations ) {
            mw.calculators.drugPopulations[ drugPopulationId ] = drugPopulations[ drugPopulationId ];
        }
    };

    mw.calculators.getDrugPopulation = function( drugPopulationId ) {
        if( mw.calculators.drugPopulations.hasOwnProperty( drugPopulationId ) ) {
            return mw.calculators.drugPopulations[ drugPopulationId ];
        } else {
            return null;
        }
    };



    /**
     * Class DrugPopulation
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugPopulation}
     * @constructor
     */
    mw.calculators.objectClasses.DrugPopulation = function( propertyValues ) {
        var properties = {
            required: [
                'id',
                'name'
            ],
            optional: [
                'abbreviation',
                'variables'
            ]
        };

        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );

        if( this.variables ) {
            for( var variableId in this.variables ) {
                if( !mw.calculators.getVariable( variableId ) ) {
                    throw new Error( 'DrugPopulation variable "' + variableId + '" not defined' );
                }

                this.variables[ variableId ].min = this.variables[ variableId ].hasOwnProperty( 'min' ) ?
                    math.unit( this.variables[ variableId ].min ) : null;

                this.variables[ variableId ].max = this.variables[ variableId ].hasOwnProperty( 'max' ) ?
                    math.unit( this.variables[ variableId ].max ) : null;
            }
        } else {
            this.variables = {};
        }
    };

    mw.calculators.objectClasses.DrugPopulation.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );

    mw.calculators.objectClasses.DrugPopulation.prototype.getCalculationData = function() {
        var inputData = new mw.calculators.objectClasses.CalculationData();

        for( var variableId in this.variables ) {
            inputData.variables.required.push( variableId );
        }

        return inputData;
    };

    mw.calculators.objectClasses.DrugPopulation.prototype.getCalculationDataScore = function( dataValues ) {
        // A return value of -1 indicates the data did not match the population definition

        for( var variableId in this.variables ) {
            if( !dataValues.hasOwnProperty( variableId ) ) {
                return -1;
            }

            if( this.variables[ variableId ].min &&
                ( !dataValues[ variableId ] ||
                    !math.largerEq( dataValues[ variableId ], this.variables[ variableId ].min ) ) ) {
                return -1;
            }

            if( this.variables[ variableId ].max &&
                ( !dataValues[ variableId ] ||
                    !math.smallerEq( dataValues[ variableId ], this.variables[ variableId ].max ) ) ) {
                return -1;
            }
        }

        // If the data matches the population definition, the score corresponds to the number of variables in the
        // population definition. This should roughly correspond to the specificity of the population.
        return Object.keys( this.variables ).length;
    };

    mw.calculators.objectClasses.DrugPopulation.prototype.toString = function() {
        return mw.calculators.isMobile() && this.abbreviation ? this.abbreviation : this.name;
    };



    /**
     * DrugRoute
     */
    mw.calculators.drugRoutes = {};

    mw.calculators.addDrugRoutes = function( drugRouteData ) {
        var drugRoutes = mw.calculators.createCalculatorObjects( 'DrugRoute', drugRouteData );

        for( var drugRouteId in drugRoutes ) {
            mw.calculators.drugRoutes[ drugRouteId ] = drugRoutes[ drugRouteId ];
        }
    };

    mw.calculators.getDrugRoute = function( drugRouteId ) {
        if( mw.calculators.drugRoutes.hasOwnProperty( drugRouteId ) ) {
            return mw.calculators.drugRoutes[ drugRouteId ];
        } else {
            return null;
        }
    };

    /**
     * Class DrugRoute
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugRoute}
     * @constructor
     */
    mw.calculators.objectClasses.DrugRoute = function( propertyValues ) {
        var properties = {
            required: [
                'id',
                'name'
            ],
            optional: [
                'abbreviation',
                'default'
            ]
        };

        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );
    };

    mw.calculators.objectClasses.DrugRoute.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );

    mw.calculators.objectClasses.DrugRoute.prototype.toString = function() {
        return mw.calculators.isMobile() && this.abbreviation ? this.abbreviation : this.name;
    };







    /**
     * DrugIndication
     */
    mw.calculators.drugIndications = {};

    mw.calculators.addDrugIndications = function( drugIndicationData ) {
        var drugIndications = mw.calculators.createCalculatorObjects( 'DrugIndication', drugIndicationData );

        for( var drugIndicationId in drugIndications ) {
            mw.calculators.drugIndications[ drugIndicationId ] = drugIndications[ drugIndicationId ];
        }
    };

    mw.calculators.getDrugIndication = function( drugIndicationId ) {
        if( mw.calculators.drugIndications.hasOwnProperty( drugIndicationId ) ) {
            return mw.calculators.drugIndications[ drugIndicationId ];
        } else {
            return null;
        }
    };

    /**
     * Class DrugIndication
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugIndication}
     * @constructor
     */
    mw.calculators.objectClasses.DrugIndication = function( propertyValues ) {
        var properties = {
            required: [
                'id',
                'name'
            ],
            optional: [
                'abbreviation',
                'default'
            ]
        };

        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );
    };

    mw.calculators.objectClasses.DrugIndication.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );

    mw.calculators.objectClasses.DrugIndication.prototype.toString = function() {
        return mw.calculators.isMobile() && this.abbreviation ? this.abbreviation : this.name;
    };





    /**
     * Drug
     */
    mw.calculators.drugs = {};

    mw.calculators.addDrugs = function( drugData ) {
        var drugs = mw.calculators.createCalculatorObjects( 'Drug', drugData );

        for( var drugId in drugs ) {
            mw.calculators.drugs[ drugId ] = drugs[ drugId ];
        }
    };

    mw.calculators.addDrugDosages = function( drugId, drugDosageData ) {
        var drug = mw.calculators.getDrug( drugId );

        if( !drug ) {
            throw new Error( 'DrugDosage references drug "' + drugId + '" which is not defined' );
        }

        drug.addDosages( drugDosageData );

        var calculationId = 'drugDosage-' + drugId;
        var calculation = mw.calculators.getCalculation( calculationId );

        if( !calculation ) {
            var calculationData = {};

            calculationData[ calculationId ] = {
                calculate: mw.calculators.objectClasses.DrugDosageCalculation.prototype.calculate,
                drug: drugId,
                type: 'drug'
            };

            mw.calculators.addCalculations( calculationData, 'DrugDosageCalculation' );

            calculation = mw.calculators.getCalculation( calculationId );
        }

        calculation.setDependencies();
    };

    mw.calculators.getDrug = function( drugId ) {
        if( mw.calculators.drugs.hasOwnProperty( drugId ) ) {
            return mw.calculators.drugs[ drugId ];
        } else {
            return null;
        }
    };



    /**
     * Class Drug
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.Drug}
     * @constructor
     */
    mw.calculators.objectClasses.Drug = function( propertyValues ) {
        var properties = {
            required: [
                'id',
                'name'
            ],
            optional: [
                'color'
            ]
        };

        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );

        if( !this.color ) {
            this.color = DEFAULT_DRUG_COLOR;
        }

        var color = mw.calculators.getDrugColor( this.color );

        if( !color ) {
            throw new Error( 'Invalid drug color "' + this.color + '" for drug "' + this.id + '"' );
        }

        this.color = color;

        this.dosages = [];
        this.preparations = [];
    };

    mw.calculators.objectClasses.Drug.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );

    mw.calculators.objectClasses.Drug.prototype.addDosages = function( drugDosageData ) {
        var dosages = mw.calculators.createCalculatorObjects( 'DrugDosage', drugDosageData );

        for( var dosageId in dosages ) {
            dosages[ dosageId ].id = this.dosages.length;

            this.dosages.push( dosages[ dosageId ] );
        }
    };

    mw.calculators.objectClasses.Drug.prototype.getIndications = function() {
        var indications = [];

        for( var iDosage in this.dosages ) {
            if( this.dosages[ iDosage ].indication ) {
                indications.push( this.dosages[ iDosage ].indication );
            }
        }

        return indications.filter( mw.calculators.uniqueValues );
    };

    mw.calculators.objectClasses.Drug.prototype.getPopulations = function( indicationId ) {
        var populations = [];

        for( var iDosage in this.dosages ) {
            if( this.dosages[ iDosage ].population &&
                ( !indicationId || ( this.dosages[ iDosage ].indication && this.dosages[ iDosage ].indication.id === indicationId ) ) ) {
                populations.push( this.dosages[ iDosage ].population );
            }
        }

        return populations.filter( mw.calculators.uniqueValues );
    };

    mw.calculators.objectClasses.Drug.prototype.getRoutes = function( indicationId ) {
        var routes = [];

        for( var iDosage in this.dosages ) {
            if( this.dosages[ iDosage ].route &&
                ( !indicationId || ( this.dosages[ iDosage ].indication && this.dosages[ iDosage ].indication.id === indicationId ) ) ) {
                routes.push( this.dosages[ iDosage ].route );
            }
        }

        return routes.filter( mw.calculators.uniqueValues );
    };

    mw.calculators.objectClasses.Drug.prototype.getPreparations = function() {
        return this.preparations.filter( mw.calculators.uniqueValues );
    };





    /**
     * DrugPreparation
     */
    mw.calculators.addDrugPreparations = function( drugId, drugPreparationData ) {
        if( !mw.calculators.getDrug( drugId ) ) {
            throw new Error( 'DrugPreparation references drug "' + drugId + '" which is not defined' );
        }

        for( var drugPreparationId in drugPreparationData ) {
            drugPreparationData[ drugPreparationId ].drug = drugId;
        }

        var drugPreparations = mw.calculators.createCalculatorObjects( 'DrugPreparation', drugPreparationData );

        for( var drugPreparationId in drugPreparations ) {
            mw.calculators.drugs[ drugId ].preparations[ drugPreparationId ] = drugPreparations[ drugPreparationId ];
        }
    };



    /**
     * Class DrugPreparation
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugPreparation}
     * @constructor
     */
    mw.calculators.objectClasses.DrugPreparation = function( propertyValues ) {
        var properties = {
            required: [
                'drug',
                'id',
                'concentration'
            ],
            optional: [
                'default',
                'dilutionRequired',
                'commonDilution'
            ]
        };

        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );


        this.concentration = this.concentration.replace( 'mcg', 'ug' );

        this.concentration = math.unit( this.concentration );
    };

    mw.calculators.objectClasses.DrugPreparation.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );

    mw.calculators.objectClasses.DrugPreparation.prototype.getVolumeUnits = function() {
        // The units of concentration will always be of the form "mass / volume"
        // The regular expression matches all text leading up to the volume units
        return mw.calculators.getUnitsByBase( this.concentration ).volume;
    };

    mw.calculators.objectClasses.DrugPreparation.prototype.toString = function() {
        return mw.calculators.getValueString( this.concentration );
    };





    /**
     * Class DrugDosage
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugDosage}
     * @constructor
     */
    mw.calculators.objectClasses.DrugDosage = function( propertyValues ) {
        mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues );

        var drugIndication = mw.calculators.getDrugIndication( this.indication );

        if( !drugIndication ) {
            throw new Error( 'Invalid indication "' + this.indication + '" for drug dosage' );
        }

        this.indication = drugIndication;

        this.population = this.population ? this.population : DEFAULT_DRUG_POPULATION;

        var drugPopulation = mw.calculators.getDrugPopulation( this.population );

        if( !drugPopulation ) {
            throw new Error( 'Invalid population "' + this.population + '" for drug dosage' );
        }

        this.population = drugPopulation;

        this.route = this.route ? this.route : DEFAULT_DRUG_ROUTE;

        var drugRoute = mw.calculators.getDrugRoute( this.route );

        if( !drugRoute ) {
            throw new Error( 'Invalid route "' + this.route + '" for drug dosage' );
        }

        this.route = drugRoute;

        // Add the dose objects to the drug
        var drugDoseData = this.dose;
        this.dose = [];

        this.addDoses( drugDoseData );
    };

    mw.calculators.objectClasses.DrugDosage.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );

    mw.calculators.objectClasses.DrugDosage.prototype.addDoses = function( drugDoseData ) {
        // Each dosage can have one or more associated doses. Ensure this value is an array.
        if( !Array.isArray( drugDoseData ) ) {
            drugDoseData = [ drugDoseData ];
        }

        var doses = mw.calculators.createCalculatorObjects( 'DrugDose', drugDoseData );

        for( var doseId in doses ) {
            doses[ doseId ].id = this.dose.length;

            this.dose.push( doses[ doseId ] );
        }
    };

    mw.calculators.objectClasses.DrugDosage.prototype.getCalculationData = function() {
        var inputData = new mw.calculators.objectClasses.CalculationData();

        inputData = inputData.merge( this.population.getCalculationData() );

        for( var iDose in this.dose ) {
            inputData = inputData.merge( this.dose[ iDose ].getCalculationData() );
        }

        return inputData;
    };

    mw.calculators.objectClasses.DrugDosage.prototype.getProperties = function() {
        return {
            required: [
                'dose',
                'id',
                'indication'
            ],
            optional: [
                'description',
                'population',
                'route'
            ]
        };
    };

    mw.calculators.objectClasses.DrugDosage.prototype.hasInfo = function() {
        return this.description;
    };





    /**
     * Class DrugDose
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugDose}
     * @constructor
     */
    mw.calculators.objectClasses.DrugDose = function( propertyValues ) {
        mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues );

        var mathProperties = this.getMathProperties();

        for( var iMathProperty in mathProperties ) {
            var mathProperty = mathProperties[ iMathProperty ];

            if( this[ mathProperty ] ) {
                // TODO consider making a UnitsBase.weight.fromString()
                this[ mathProperty ] = this[ mathProperty ].replace( 'kg', 'kgwt' );
                this[ mathProperty ] = this[ mathProperty ].replace( 'mcg', 'ug' );

                this[ mathProperty ] = math.unit( this[ mathProperty ] );
            } else {
                this[ mathProperty ] = null;
            }
        }

        if( this.weightCalculation ) {
            var weightCalculation = mw.calculators.getCalculation( this.weightCalculation );

            if( !weightCalculation ) {
                throw new Error( 'Drug dose references weight calculation "' + this.weightCalculation + '" which is not defined' );
            }

            this.weightCalculation = weightCalculation;
        }
    };

    mw.calculators.objectClasses.DrugDose.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );

    mw.calculators.objectClasses.DrugDose.prototype.getAdministration = function() {
        var administration = '';

        if( this.frequency ) {
            administration += administration ? ' ' : '';
            administration += this.frequency;
        }

        if( this.duration ) {
            administration += administration ? ' ' : '';
            administration += 'over ' + this.duration;
        }

        return administration;
    };

    mw.calculators.objectClasses.DrugDose.prototype.getCalculationData = function() {
        var calculationData = new mw.calculators.objectClasses.CalculationData();

        var mathProperties = this.getMathProperties();

        // Look at dose properties to identify any variable dependence (e.g. weight-dependence)
        for( var iMathProperty in mathProperties ) {
            var mathProperty = mathProperties[ iMathProperty ];

            var dosePropertyValue = this[ mathProperty ];

            // For now, this only supports weight dependence, unclear if it will need to be more generalizable in the future
            if( mw.calculators.isValueDependent( dosePropertyValue, 'weight' ) &&
                calculationData.variables.optional.indexOf( 'weight' ) === -1 ) {
                calculationData.variables.optional.push( 'weight' );
            }
        }

        if( this.weightCalculation ) {
            calculationData.calculations.optional.push( this.weightCalculation.id );
        }

        return calculationData;
    };

    mw.calculators.objectClasses.DrugDose.prototype.getMathProperties = function() {
        return [
            'dose',
            'min',
            'max',
            'absoluteMin',
            'absoluteMax'
        ];
    };

    mw.calculators.objectClasses.DrugDose.prototype.getProperties = function() {
        return {
            required: [
                'id'
            ],
            optional: [
                'absoluteMin',
                'absoluteMax',
                'dose',
                'duration',
                'frequency',
                'min',
                'max',
                'name',
                'weightCalculation'
            ]
        };
    };




    /**
     * Class DrugDosageCalculation
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugDosageCalculation}
     * @constructor
     */
    mw.calculators.objectClasses.DrugDosageCalculation = function( propertyValues ) {
        mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues );

        this.initialize();
    };

    mw.calculators.objectClasses.DrugDosageCalculation.prototype = Object.create( mw.calculators.objectClasses.AbstractCalculation.prototype );

    mw.calculators.objectClasses.DrugDosageCalculation.prototype.calculate = function( data ) {
        var value = {
            dosageId: null,
            population: null,
            preparation: data.preparation,
            dose: []
        };

        // Determine which dosage to use
        var populationScores = [];

        for( var iDosage in data.drug.dosages ) {
            var drugDosage = data.drug.dosages[ iDosage ];

            // If the indication and route do not match, set the score to -1
            var populationScore =
                drugDosage.indication.id === data.indication.id && drugDosage.route.id === data.route.id ?
                drugDosage.population.getCalculationDataScore( data ) : -1;

            populationScores.push( populationScore );
        }

        var maxPopulationScore = Math.max.apply( null, populationScores );

        if( maxPopulationScore < 0 ) {
            return value;
        }

        // If there is more than one dosage with the same score, take the first.
        // This allows the data editor to decide which is most important.
        value.dosageId = populationScores.indexOf( maxPopulationScore );

        var dosage = data.drug.dosages[ value.dosageId ];

        // A dosage may contain multiple doses (e.g. induction and maintenance)
        for( var iDose in dosage.dose ) {
            var dose = dosage.dose[ iDose ];
            var mathProperties = dose.getMathProperties();

            var weightValue = dose.weightCalculation && dose.weightCalculation.value ? dose.weightCalculation.value : data.weight;

            // Initialize value properties for dose
            value.dose[ iDose ] = {
                massPerWeight: {
                    decimals: 0
                },
                mass: {
                    decimals: 0
                },
                volume: {
                    decimals: 0
                },
                weightCalculation: weightValue ? weightValue : null
            };

            var massUnits;
            var volumeUnits;

            for( var iMathProperty in mathProperties ) {
                var mathProperty = mathProperties[ iMathProperty ];

                var doseValue = dose[ mathProperty ];

                if( doseValue ) {
                    var doseValueDecimals = mw.calculators.getValueDecimals( doseValue );
                    var doseUnitsByBase = mw.calculators.getUnitsByBase( doseValue );

                    if( doseUnitsByBase.hasOwnProperty( 'weight' ) ) {
                        value.dose[ iDose ].massPerWeight[ mathProperty ] = doseValue;

                        // Set the decimals based upon the specified dose
                        value.dose[ iDose ].massPerWeight.decimals = math.max(
                            doseValueDecimals,
                            value.dose[ iDose ].massPerWeight.decimals
                        );

                        if( weightValue ) {
                            massUnits = doseUnitsByBase.mass;

                            if( doseUnitsByBase.hasOwnProperty( 'time' ) ) {
                                massUnits += '/' + doseUnitsByBase.time;
                            }

                            // For whatever reason math.format will simplify the units, but math.formatUnits will not
                            // as a hack, we recreate a new unit value with the correct formatting of the result
                            value.dose[ iDose ].mass[ mathProperty ] = math.unit( math.multiply( doseValue, weightValue ).format() ).to( massUnits );

                            // Mass should use one fewer decimals than massPerWeight (unless already 0)
                            value.dose[ iDose ].mass.decimals = math.max(
                                math.max( doseValueDecimals - 1, 0 ),
                                value.dose[ iDose ].mass.decimals
                            );
                        }
                    } else {
                        value.dose[ iDose ].mass[ mathProperty ] = doseValue;

                        // Set the decimals based upon the specified dose
                        value.dose[ iDose ].mass.decimals = math.max(
                            doseValueDecimals,
                            value.dose[ iDose ].mass.decimals
                        );
                    }

                    if( data.preparation && value.dose[ iDose ].mass[ mathProperty ] ) {
                        // Same hack as above to get units to simplify correctly
                        var preparationUnitsByBase = mw.calculators.getUnitsByBase( data.preparation.concentration );

                        volumeUnits = preparationUnitsByBase.volume;

                        if( doseUnitsByBase.hasOwnProperty( 'time' ) ) {
                            volumeUnits += '/' + doseUnitsByBase.time;
                        }

                        value.dose[ iDose ].volume[ mathProperty ] = math.unit( math.multiply( value.dose[ iDose ].mass[ mathProperty ], math.divide( 1, data.preparation.concentration ) ).format() ).to( volumeUnits );

                        var volumeNumeric = value.dose[ iDose ].volume[ mathProperty ].toNumber();

                        if( volumeNumeric < 2 ) {
                            value.dose[ iDose ].volume.decimals = 1;
                        } else if( volumeNumeric < 0.2 ) {
                            value.dose[ iDose ].volume.decimals = 2;
                        }
                    }
                }
            }
        }

        return value;
    };

    mw.calculators.objectClasses.DrugDosageCalculation.prototype.doRender = function() {
        var $calculationContainer = $( '.' + this.getContainerClass() );

        if( !$calculationContainer.length ) {
            return;
        }

        $calculationContainer.empty();

        // Label column
        var labelAttributes = {
            class: 'calculator-DrugDosageCalculator-drug-value'
        };

        var labelCss = {};

        var $label = $( '<th>', labelAttributes ).css( labelCss );

        $label.append( this.getLabelHtml() );

        var $infoButton = null;

        if( this.hasInfo() ) {
            $infoButton = $( '<a>', {
                'data-toggle': 'collapse',
                href: '#' + this.getContainerClass() + '-info',
                role: 'button',
                'aria-expanded': 'false',
                'aria-controls': this.getContainerClass() + '-info'
            } )
                .append( $( '<i>', {
                    class: 'far fa-question-circle'
                } ) );

            $label
                .append( $( '<span>', {
                    class: 'calculator-calculation-column-label-info'
                } )
                    .append( $infoButton )
                );
        }

        // Dosage column

        var $dosage = $( '<td>', {
            class: 'calculator-DrugDosageCalculator-dose-value'
        }  );

        var dash = '-';

        // The options column should only show the preparation if there is a calculated volume
        var hasVolume;

        if( this.value ) {
            var dosage = this.drug.dosages[ this.value.dosageId ];

            var showInfo;

            var $doseInfo = $( '<div>', {
                class: 'calculator-DrugDosageCalculator-dose-info'
            } );

            if( dosage.population && dosage.population.id !== DEFAULT_DRUG_POPULATION ) {
                $doseInfo
                    .append( $( '<div>', {
                        class: 'calculator-DrugDosageCalculator-dose-info-population'
                    } ).append( String( dosage.population ) + ' dosing' ) );

                showInfo = true;
            }

            if( dosage.hasInfo() ) {
                var dosageInfoText = mw.calculators.isMobile() ? 'Dosage info' : 'Dosage information';

                var $dosageInfoLink = $( '<a>', {
                    'data-toggle': 'collapse',
                    href: '#' + this.getContainerClass() + '-dose-info-row',
                    role: 'button',
                    'aria-expanded': 'false',
                    'aria-controls': this.getContainerClass() + '-dose-info-row'
                } )
                    .append( dosageInfoText + '&nbsp;' )
                    .append( $( '<i>', {
                        class: 'far fa-question-circle'
                    } ) );

                $doseInfo
                    .append( $( '<div>', {
                        class: 'calculator-DrugDosageCalculator-dose-info-button'
                    } ).append( $dosageInfoLink ) );

                showInfo = true;
            }

            if( showInfo ) {
                $dosage.append( $doseInfo );
            }

            // This will iterate through the calculated doses. iDose should exactly correspond to doses within dosage
            // to allow referencing other properties of the dose.
            for( var iDose in this.value.dose ) {
                var dose = dosage.dose[ iDose ];

                var doseValue = this.value.dose[ iDose ];

                var makeList;

                if( dose.name ) {
                    $dosage.append( dose.name + '<br />' );

                    makeList = true;
                }

                if( makeList ) {
                    $dosage.append( '<ul>' );
                }

                var administration = dose.getAdministration();
                var administrationDisplayed = false;

                var massPerWeightHtml = '';

                if( doseValue.massPerWeight.hasOwnProperty( 'dose' ) ) {
                    massPerWeightHtml += mw.calculators.getValueString( doseValue.massPerWeight.dose, doseValue.massPerWeight.decimals );
                } else if( doseValue.massPerWeight.hasOwnProperty( 'min' ) &&
                    doseValue.massPerWeight.hasOwnProperty( 'max' ) ) {
                    massPerWeightHtml += mw.calculators.getValueNumber( doseValue.massPerWeight.min, doseValue.massPerWeight.decimals );
                    massPerWeightHtml += dash;
                    massPerWeightHtml += mw.calculators.getValueString( doseValue.massPerWeight.max, doseValue.massPerWeight.decimals );
                }

                if( massPerWeightHtml ) {
                    if( administration && ! administrationDisplayed ) {
                        massPerWeightHtml += ' ' + administration;
                        administrationDisplayed = true;
                    }

                    if( dose.weightCalculation ) {
                        massPerWeightHtml += ' (' + dose.weightCalculation.getLabelString() + ')';
                    }

                    if( makeList ) {
                        massPerWeightHtml = $( '<li>' ).append( massPerWeightHtml );
                    }

                    $dosage.append( massPerWeightHtml );

                    if( !makeList ) {
                        $dosage.append( '<br />' );
                    }
                }

                var massHtml = '';

                if( doseValue.mass.hasOwnProperty( 'dose' ) ) {
                    massHtml += mw.calculators.getValueString( doseValue.mass.dose, doseValue.mass.decimals );
                } else if( doseValue.mass.hasOwnProperty( 'min' ) &&
                    doseValue.mass.hasOwnProperty( 'max' ) ) {
                    massHtml += mw.calculators.getValueNumber( doseValue.mass.min, doseValue.mass.decimals );
                    massHtml += dash;
                    massHtml += mw.calculators.getValueString( doseValue.mass.max, doseValue.mass.decimals );
                }

                if( massHtml ) {
                    if( administration && ! administrationDisplayed ) {
                        massHtml += ' ' + administration;
                        administrationDisplayed = true;
                    }

                    if( false && dose.weightCalculation && doseValue.weightCalculation.id !== dose.weightCalculation.id ) {
                        // TODO fix
                        weightCalculationLabel = !mw.calculators.isMobile() ? 'Total body weight' : 'TBW';

                        massHtml += '&nbsp; (' + weightCalculationLabel + '&nbsp;' + $( '<i>', {
                            class: 'far fa-question-circle'
                        } )[ 0 ].outerHTML + ')';
                    }

                    if( makeList ) {
                        massHtml = $( '<li>' ).append( massHtml );
                    }

                    $dosage.append( massHtml );

                    if( !makeList ) {
                        $dosage.append( '<br />' );
                    }
                }

                var volumeHtml = '';

                if( doseValue.volume.hasOwnProperty( 'dose' ) ) {
                    volumeHtml += mw.calculators.getValueString( doseValue.volume.dose, doseValue.volume.decimals );
                } else if( doseValue.volume.hasOwnProperty( 'min' ) &&
                    doseValue.volume.hasOwnProperty( 'max' ) ) {
                    volumeHtml += mw.calculators.getValueNumber( doseValue.volume.min, doseValue.volume.decimals );
                    volumeHtml += dash;
                    volumeHtml += mw.calculators.getValueString( doseValue.volume.max, doseValue.volume.decimals );
                }

                if( volumeHtml ) {
                    if( administration && ! administrationDisplayed ) {
                        volumeHtml += ' ' + administration;
                        administrationDisplayed = true;
                    }

                    if( makeList ) {
                        volumeHtml = $( '<li>' ).append( volumeHtml );
                    }

                    $dosage.append( volumeHtml );

                    if( !makeList ) {
                        $dosage.append( '<br />' );
                    }

                    hasVolume = true;
                }

                if( makeList ) {
                    $dosage.append( '</ul>' );
                }
            }
        }


        // Options column
        var $options = $( '<td>', {
            class: 'calculator-DrugDosageCalculator-options-value'
        } );

        var indications = this.drug.getIndications();

        if( indications.length ) {
            $options.append( mw.calculators.getVariable( this.getVariableIds().indication ).createInput({
                class: 'calculator-container-input-DrugDosageCalculator-options',
                hideLabelMobile: true,
                inline: true
            } ) );
        }

        var routes = this.drug.getRoutes();

        if( routes.length ) {
            $options.append( mw.calculators.getVariable( this.getVariableIds().route  ).createInput({
                class: 'calculator-container-input-DrugDosageCalculator-options',
                hideLabelMobile: true,
                inline: true
            } ) );
        }

        // Don't show preparations if there isn't a dose with volume
        if( hasVolume ) {
            var preparations = this.drug.getPreparations();

            if( preparations.length ) {
                $options.append( mw.calculators.getVariable( this.getVariableIds().preparation  ).createInput({
                    class: 'calculator-container-input-DrugDosageCalculator-options',
                    hideLabelMobile: true,
                    inline: true
                } ) );
            }
        }

        $calculationContainer
            .append(
                $label,
                $dosage,
                $options
            );


        return;



        var calculation = this;

        $calculationContainer.each( function() {
            $( this ).empty();




            if( calculation.hasInfo() ) {
                var infoHtml = '';

                if( calculation.description ) {
                    infoHtml += $( '<p>', {
                        html: calculation.description
                    } )[ 0 ].outerHTML;
                }

                if( calculation.formula ) {
                    infoHtml += $( '<span>', {
                        class: calculation.getContainerClass() + '-formula'
                    } )[ 0 ].outerHTML;

                    var api = new mw.Api();

                    api.parse( calculation.formula ).then( function( result ) {
                        $( '.' + calculation.getContainerClass() + '-formula' ).html( result );
                    } );
                }

                if( calculation.references.length ) {
                    var $references = $( '<ol>' );

                    for( var iReference in calculation.references ) {
                        $references.append( $( '<li>', {
                            text: calculation.references[ iReference ]
                        } ) );
                    }

                    infoHtml += $references[ 0 ].outerHTML;
                }

                var infoContainerId = calculation.getContainerClass() + '-info';
                var $infoContainer = $( '#' + infoContainerId );

                if( $infoContainer.length ) {
                    $infoContainer.empty();
                }

                $infoContainer = $( '<tr>', {
                    id: infoContainerId,
                    class: 'collapse'
                } )
                    .append( $( '<td>', {
                        colspan: 2
                    } ).append( infoHtml ) );


                $( this ).after( $infoContainer );
            }
        } );
    };

    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getCalculationData = function() {
        var inputData = new mw.calculators.objectClasses.CalculationData();

        // Add variables created by this calculation
        var variableIds = this.getVariableIds();

        for( var variableType in variableIds ) {
            inputData.variables.optional.push( variableIds[ variableType ] );
        }

        var dataTypes = inputData.getDataTypes();

        // Data is only actually required if it is required by every dosage for the drug.
        // Data marked as required by an individual dosage that does not appear in every
        // dosage will be converted to optional.
        var requiredInputData = new mw.calculators.objectClasses.CalculationData();

        // Need a way to tell the first iteration of the loop to initialize the required variables to a value that
        // is distinct from the empty array (populated across loop using array intersect, so could become [] and shouldn't
        // reinitialize).
        var initializeRequiredData = true;

        // Iterate through each dosage to determine variable dependency
        for( var iDosage in this.drug.dosages ) {
            var dosageInputData = this.drug.dosages[ iDosage ].getCalculationData();

            inputData = inputData.merge( dosageInputData );

            for( var iDataType in dataTypes ) {
                var dataType = dataTypes[ iDataType ];

                if( initializeRequiredData ) {
                    requiredInputData[ dataType ].required = inputData[ dataType ].required;
                } else {
                    // Data is only truly required if it is required by all dosage calculations, so use array intersection
                    requiredInputData[ dataType ].required = requiredInputData[ dataType ].required.filter( function( index ) {
                        return dosageInputData[ dataType ].required.indexOf( index ) !== -1;
                    } );
                }
            }

            initializeRequiredData = false;
        }

        for( var iDataType in dataTypes ) {
            var dataType = dataTypes[ iDataType ];

            // Move any data marked required in inputData to optional if it not actually required (i.e. doesn't appear
            // in requiredInputData).
            inputData[ dataType ].optional = inputData[ dataType ].optional.concat( inputData[ dataType ].required.filter( function( index ) {
                return requiredInputData[ dataType ].required.indexOf( index ) === -1;
            } ) ).filter( mw.calculators.uniqueValues );

            inputData[ dataType ].required = requiredInputData[ dataType ].required;
        }

        return inputData;
    };

    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getCalculationDataValues = function() {
        var data = mw.calculators.objectClasses.AbstractCalculation.prototype.getCalculationDataValues.call( this );

        data.drug = this.drug;

        data.indication = data[ this.getVariablePrefix() + 'indication' ] ?
            mw.calculators.getDrugIndication( mw.calculators.getVariable( this.getVariableIds().indication ).value ) :
            null;

        delete data[ this.getVariablePrefix() + 'indication' ];

        data.preparation = data[ this.getVariablePrefix() + 'preparation' ] ?
            this.drug.preparations[ mw.calculators.getVariable( this.getVariableIds().preparation ).value ] :
            null;

        delete data[ this.getVariablePrefix() + 'preparation' ];

        data.route = data[ this.getVariablePrefix() + 'route' ] ?
            mw.calculators.getDrugRoute( mw.calculators.getVariable( this.getVariableIds().route ).value ) :
            null;

        delete data[ this.getVariablePrefix() + 'preparation' ];

        return data;
    };


    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getLabelHtml = function() {
        var $label = $( '<a>', {
            href: mw.util.getUrl( this.drug.name ),
            text: this.drug.name
        } ).css( 'background-color', '#fff' );

        var highlightColor = this.drug.color.getHighlightColor();

        if( highlightColor ) {
            var highlightContainerAttributes = {
                class: 'calculator-DrugDosageCalculator-drug-highlight'
            };

            var highlightContainerCss = {};

            highlightContainerCss[ 'background' ] = highlightColor;

            $label = $( '<span>', highlightContainerAttributes ).append( $label ).css( highlightContainerCss );
        }

        var primaryColor = this.drug.color.getPrimaryColor();

        if( primaryColor ) {
            var backgroundContainerAttributes = {
                class: 'calculator-DrugDosageCalculator-drug-background'
            };

            var backgroundContainerCss = {};

            if( this.drug.color.isStriped() ) {
                backgroundContainerCss[ 'background' ] = 'repeating-linear-gradient(135deg,rgba(0,0,0,0),rgba(0,0,0,0)10px,rgba(255,255,255,1)10px,rgba(255,255,255,1)20px),' + primaryColor;
            } else {
                backgroundContainerCss[ 'background'] = primaryColor;
            }

            $label = $( '<span>', backgroundContainerAttributes ).append( $label ).css( backgroundContainerCss );
        }

        return $label;
    };

    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getProperties = function() {
        var inheritedProperties = mw.calculators.objectClasses.AbstractCalculation.prototype.getProperties();

        return this.mergeProperties( inheritedProperties, {
            required: [
                'drug'
            ],
            optional: []
        } );
    };

    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getVariableIds = function() {
        return {
            indication: this.getVariablePrefix() + 'indication',
            preparation: this.getVariablePrefix() + 'preparation',
            route: this.getVariablePrefix() + 'route'
        };
    };

    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getVariablePrefix = function() {
        return this.drug.id + '-';
    }

    mw.calculators.objectClasses.DrugDosageCalculation.prototype.initialize = function() {
        mw.calculators.objectClasses.AbstractCalculation.prototype.initialize.call( this );

        var drug = mw.calculators.getDrug( this.drug );

        if( !drug ) {
            throw new Error( 'DrugDosage references drug "' + this.drug + '" which is not defined' );
        }

        this.drug = drug;

        var variableIds = this.getVariableIds();

        // Create variables for indication, population?, preparation select boxes? Here or m.c.addDosages() or elsewhere?
        // Will have to add them to getCalculationData too.
        var drugVariables = {};

        var indications = this.drug.getIndications();
        var indicationOptions = {};
        var defaultIndication = 0;

        for( var iIndication in indications ) {
            var indication = indications[ iIndication ];

            defaultIndication = indication.default ? iIndication : defaultIndication;

            indicationOptions[ indication.id ] = String( indication );
        }

        drugVariables[ variableIds.indication ] = {
            name: 'Indication',
            type: 'string',
            defaultValue: indications.length ? indications[ defaultIndication ].id : null,
            options: indicationOptions
        };

        var preparations = this.drug.getPreparations();

        var preparationOptions = {};
        var defaultPreparation = 0;

        for( var iPreparation in preparations ) {
            var preparation = preparations[ iPreparation ];

            // We don't want to display any preparations which cannot be directly administered
            if( preparation.dilutionRequired ) {
                continue;
            }

            defaultPreparation = preparation.default ? iPreparation : defaultPreparation;

            preparationOptions[ preparation.id ] = String( preparation );
        }

        drugVariables[ variableIds.preparation ] = {
            name: 'Preparation',
            type: 'string',
            defaultValue: preparations.length ? preparations[ defaultPreparation ].id : null,
            options: preparationOptions
        };

        var routes = this.drug.getRoutes();
        var routeOptions = {};
        var defaultRoute = 0;

        for( var iRoute in routes ) {
            var route = routes[ iRoute ];

            defaultRoute = route.default ? iRoute : defaultRoute;

            routeOptions[ route.id ] = String( route );
        }

        drugVariables[ variableIds.route ] = {
            name: 'Route',
            type: 'string',
            defaultValue: routes.length ? routes[ defaultRoute ].id : null,
            options: routeOptions
        };

        mw.calculators.addVariables( drugVariables );
    };





    /**
     * Class DrugDosageCalculator
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugDosageCalculator}
     * @constructor
     */
    mw.calculators.objectClasses.DrugDosageCalculator = function( propertyValues ) {
        mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues );
    };

    mw.calculators.objectClasses.DrugDosageCalculator.prototype = Object.create( mw.calculators.objectClasses.AbstractCalculator.prototype );

    mw.calculators.objectClasses.DrugDosageCalculator.prototype.doRender = function() {
        var $calculatorContainer = $( '.' + this.getContainerClass() );

        if( !$calculatorContainer.length ) {
            return;
        }

        $calculatorContainer.addClass( this.getCalculatorClass() );

        $calculatorContainer.empty();

        $calculatorContainer.append( $( '<h4>', {
            text: this.name
        } ) );

        var $calculationsContainer = $( '<table>', {
            class: 'wikitable'
        } ).append( '<tbody>' );

        $calculatorContainer.append( $calculationsContainer );

        $calculationsContainer
            .append( $( '<tr>' )
                .append(
                    $( '<th>', {
                        class: this.getCalculatorClass() + '-drug'
                    } ).text( 'Drug' ),
                    $( '<th>', {
                        class: this.getCalculatorClass() + '-dose'
                    }  ).text( 'Dose' ),
                    $( '<th>', {
                        class: this.getCalculatorClass() + '-options'
                    }  ).text( 'Options' )
                )
            );

        for( var iCalculationId in this.calculations ) {
            var calculation = mw.calculators.getCalculation( this.calculations[ iCalculationId ] );
            var calculationContainerClass = calculation.getContainerClass();

            var $calculationContainer = $( '<tr>', {
                class: calculationContainerClass
            } );

            $calculationsContainer.append( $calculationContainer );

            calculation.render();
        }
    };

    mw.calculators.objectClasses.DrugDosageCalculator.prototype.getCalculatorClass = function() {
        return 'calculator-DrugDosageCalculator';
    };

    mw.calculators.objectClasses.DrugDosageCalculator.prototype.getProperties = function() {
        var inheritedProperties = mw.calculators.objectClasses.AbstractCalculator.prototype.getProperties();

        return this.mergeProperties( inheritedProperties, {
            required: [],
            optional: []
        } );
    };

}() );