Difference between revisions of "MediaWiki:Gadget-calculator-anatomyPhysiology.js"

Revision as of 02:43, 21 August 2021

( function() {
    var moduleId = 'anatomyPhysiology';

    mw.calculators.addUnitsBases( {
        bpm: {
            toString: function( units ) {
                units = units.replace( 'bpm', 'beats/min' );

                return units;
            }
        },
        hgb: {
            toString: function( units ) {
                units = units.replace( 'hgbperdL', '/dL' );
                units = units.replace( 'pcthct', '%' );

                return units;
            }
        },
        o2: {
            toString: function( units ) {
                units = units.replace( 'pcto2', '%' );

                return units;
            }
        }
    } );

    mw.calculators.addUnits( {
        bpm: {
            basename: 'bpm'
        },
        pcthct: {
            baseName: 'hgb'
        },
        pcto2: {
            baseName: 'o2'
        },
        ghgbperdL: {
            baseName: 'hgb',
            prefixes: 'short',
            definition: '3 pcthct'
        }
    } );

    mw.calculators.addVariables( {
        caseDuration: {
            name: 'Case duration',
            type: 'number',
            abbreviation: 'Duration',
            maxLength: 3,
            units: [
                'hr',
                'min'
            ]
        },
        hct: {
            name: 'Current hematocrit',
            type: 'number',
            abbreviation: 'Current hct',
            defaultValue: '45 pcthct',
            maxLength: 4,
            units: [
                'pcthct',
                'ghgbperdL'
            ]
        },
        heartRate: {
            name: 'Heart rate',
            type: 'number',
            abbreviation: 'HR',
            defaultValue: '60 bpm',
            maxLength: 4,
            units: [
                'bpm'
            ]
        },
        hgb: {
            name: 'Hemoglobin',
            type: 'number',
            abbreviation: 'HgB',
            defaultValue: '13 ghgbperdL',
            maxLength: 4,
            units: [
                'pcthct',
                'ghgbperdL'
            ]
        },
        minHct: {
            name: 'Minimum hematocrit',
            type: 'number',
            abbreviation: 'Min hct',
            defaultValue: '21 pcthct',
            maxLength: 4,
            units: [
                'pcthct',
                'ghgbperdL'
            ]
        },
        paCO2: {
            name: 'PaCO<sub>2</sub>',
            type: 'number',
            abbreviation: 'PaCO<sub>2</sub>',
            defaultValue: '40 mmHg',
            maxLength: 3,
            units: [
                'mmHg'
            ]
        },
        saO2: {
            name: 'SaO<sub>2</sub>',
            type: 'number',
            abbreviation: 'SaO<sub>2</sub>',
            defaultValue: '100 pcto2',
            maxLength: 3,
            units: [
                'pcto2'
            ]
        },
        smvO2: {
            name: 'SmvO<sub>2</sub>',
            type: 'number',
            abbreviation: 'SmvO<sub>2</sub>',
            defaultValue: '75 pcto2',
            maxLength: 3,
            units: [
                'pcto2'
            ]
        },
        npoTime: {
            name: 'Time spent NPO',
            type: 'number',
            abbreviation: 'NPO time',
            defaultValue: '8 hr',
            maxLength: 2,
            units: [
                'hr'
            ]
        },
        surgicalTrauma: {
            name: 'Severity of surgical trauma',
            type: 'string',
            abbreviation: 'Surgical trauma',
            defaultValue: 'Minimal',
            options: [
                'Minimal',
                'Moderate',
                'Severe'
            ]
        }
    } );



    mw.calculators.addCalculations( {
        bmi: {
            name: 'Body mass index',
            abbreviation: 'BMI',
            data: {
                variables: {
                    required: [ 'weight', 'height' ]
                }
            },
            digits: 0,
            units: 'kg/m^2',
            formula: '<math>\\mathrm{BMI} = \\frac{\\mathrm{mass_{kg}}}{{\\mathrm{height_{m}}}^2}</math>',
            link: '[[Body mass index]]',
            references: [],
            calculate: function( data ) {
                return data.weight.toNumber( 'kgwt' ) / Math.pow( data.height.toNumber( 'm' ), 2 );
            }
        },
        bsa: {
            name: 'Body surface area',
            abbreviation: 'BSA',
            data: {
                variables: {
                    required: [ 'weight', 'height' ]
                }
            },
            digits: 2,
            units: 'm^2',
            formula: '<math>\\mathrm{BSA} = \\sqrt{\\frac{\\mathrm{weight_{kg}}*\\mathrm{height_{cm}}}{3600}}</math>',
            link: false,
            references: [
                'Mosteller RD. Simplified calculation of body-surface area. N Engl J Med. 1987 Oct 22;317(17):1098. doi: 10.1056/NEJM198710223171717. PMID: 3657876.'
            ],
            calculate: function( data ) {
                return Math.sqrt( data.height.toNumber( 'cm' ) * data.weight.toNumber( 'kgwt' ) / 3600 );
            }
        },
        ebv: {
            name: 'Estimated blood volume',
            abbreviation: 'EBV',
            data: {
                variables: {
                    required: [ 'weight', 'age' ]
                }
            },
            digits: 0,
            units: 'mL',
            formula: '',
            references: [
                'Morgan & Mikhail\'s Clinical Anesthesiology. 5e. p1168'
            ],
            calculate: function( data ) {
                var weight = data.weight.toNumber( 'kgwt' );
                var age = data.age.toNumber( 'yo' );

                var ebvPerKg;

                if( age >= 1 ) {
                    if( data.gender === 'F' ) {
                        ebvPerKg = 65;
                    } else {
                        ebvPerKg = 75;
                    }
                } else if( age >= 1/12 ) {
                    ebvPerKg = 80;
                } else if( age >= 0 ) {
                    ebvPerKg = 85;
                } else {
                    ebvPerKg = 95;
                }

                return weight * ebvPerKg;
            }
        },
        fluidMaintenanceRate: {
            name: 'Fluid maintenance rate',
            abbreviation: 'Fluid maint.',
            data: {
                variables: {
                    required: [ 'weight' ]
                }
            },
            digits: 0,
            units: 'mL/hr',
            formula: '',
            references: [
                'Miller\'s Anesthesia 7e, section IV, pg. 1728'
            ],
            calculate: function( data ) {
                var weight = data.weight.toNumber( 'kgwt' );

                // Uses 4-2-1 rule
                var maintenanceRate = 4 * Math.min( weight, 10 );

                if( weight > 10 ) {
                    maintenanceRate += 2 * Math.min( weight - 10, 10 );
                }

                if( weight > 20) {
                    maintenanceRate += weight - 20;
                }

                return maintenanceRate;
            }
        },
        intraopFluids: {
            name: 'Intraoperative fluid dosing',
            abbreviation: 'Intraop fluids',
            data: {
                calculations: {
                    required: [ 'fluidMaintenanceRate' ]
                },
                variables: {
                    required: [ 'weight', 'npoTime', 'surgicalTrauma' ]
                }
            },
            type: 'string',
            references: [
                'Corcoran T, Rhodes JE, Clarke S, Myles PS, Ho KM. Perioperative fluid management strategies in major surgery: a stratified meta-analysis. Anesth Analg. 2012 Mar;114(3):640-51. doi: 10.1213/ANE.0b013e318240d6eb. Epub 2012 Jan 16. PMID: 22253274.'
            ],
            calculate: function( data ) {
                var weight = data.weight.toNumber( 'kgwt' );
                var maintenanceRate = data.fluidMaintenanceRate.toNumber( 'mL/hr' );
                var npoTime = data.npoTime.toNumber( 'hr' );
                var surgicalTrauma = data.surgicalTrauma;

                var output = '';

                var npoDeficit = npoTime * maintenanceRate;

                var surgicalLossMin, surgicalLossMax;

                if( surgicalTrauma === 'Minimal' ) {
                    surgicalLossMin = 2 * weight;
                    surgicalLossMax = 4 * weight;
                } else if( surgicalTrauma === 'Moderate' ) {
                    surgicalLossMin = 4 * weight;
                    surgicalLossMax = 6 * weight;
                } else {
                    surgicalLossMin = 6 * weight;
                    surgicalLossMax = 8 * weight;
                }

                var firstHour = Math.round( npoDeficit / 2 ) + maintenanceRate;
                var nextHoursMin = Math.round( npoDeficit / 4 ) + maintenanceRate + surgicalLossMin;
                var nextHoursMax = Math.round( npoDeficit / 4 ) + maintenanceRate + surgicalLossMax;
                var remainingHoursMin = maintenanceRate + surgicalLossMin;
                var remainingHoursMax = maintenanceRate + surgicalLossMax;

                output += 'NPO deficit: ' + Math.round( npoDeficit ) + ' mL<br/>';
                output += 'Surgical losses: ' + surgicalLossMin + '-' + surgicalLossMax + ' mL/hr<br/>';
                output += '1st hour: ' + firstHour + ' mL<br/>';
                output += '2nd hour: ' + nextHoursMin + '-' + nextHoursMax + ' mL<br/>';
                output += '3rd hour: ' + nextHoursMin + '-' + nextHoursMax + ' mL<br/>';
                output += '4+ hours: ' + remainingHoursMin + '-' + remainingHoursMax + ' mL<br/>';

                return output;
            }
        },
        maxAbl: {
            name: 'Maximum allowable blood loss',
            abbreviation: 'Max ABL',
            data: {
                calculations: {
                    required: [ 'ebv' ]
                },
                variables: {
                    required: [ 'weight', 'age', 'hct', 'minHct' ]
                }
            },
            digits: 0,
            units: 'mL',
            formula: '',
            references: [
                'Morgan & Mikhail\'s Clinical Anesthesiology. 5e. p1168'
            ],
            calculate: function( data ) {
                var currentHct = data.hct.toNumber( 'pcthct' );
                var minHct = data.minHct.toNumber( 'pcthct' );

                if( currentHct < minHct ) {
                    return '-';
                }

                return data.ebv.toNumber( 'mL' ) * ( currentHct - minHct ) / currentHct;
            }
        },
        minUop: {
            name: 'Minimum urine output',
            abbreviation: 'Min UOP',
            data: {
                variables: {
                    required: [ 'weight', 'age' ],
                    optional: [ 'caseDuration' ]
                }
            },
            type: 'string',
            formula: '',
            references: [
                'Klahr S, Miller SB. Acute oliguria. N Engl J Med. 1998 Mar 5;338(10):671-5. doi: 10.1056/NEJM199803053381007. PMID: 9486997.',
                'Arant BS Jr. Postnatal development of renal function during the first year of life. Pediatr Nephrol. 1987 Jul;1(3):308-13. doi: 10.1007/BF00849229. PMID: 3153294.'
            ],
            calculate: function( data ) {
                var weight = data.weight.toNumber( 'kgwt' );
                var age = data.age.toNumber( 'yo' );
                var caseDuration = data.caseDuration ? data.caseDuration.toNumber( 'hr' ) : null;

                var minUop;

                if( age > 1 ) {
                    minUop = 0.5 * weight;
                } else {
                    minUop = 1 * weight;
                }

                if( caseDuration ) {
                    minUop = minUop * caseDuration + ' mL';
                } else {
                    minUop = minUop + ' mL/hr';
                }

                return minUop;
            }
        },
        systolicBloodPressure: {
            name: 'Systolic blood pressure',
            abbreviation: 'SBP',
            data: {
                variables: {
                    required: [ 'age' ]
                }
            },
            type: 'string',
            references: [
                'Baby Miller 6e, ch. 16, pg. 550'
            ],
            calculate: function( data ) {
                var age = data.age.toNumber( 'yo' );

                var systolicMin, systolicMax, diastolicMin, diastolicMax, meanMin, meanMax;

                if( age >= 16 ) {
                    systolicMin = 100;
                    systolicMax = 125;
                } else if( age >= 13 ) {
                    systolicMin = 95;
                    systolicMax = 120;
                } else if( age >= 9 ) {
                    systolicMin = 90;
                    systolicMax = 115;
                } else if( age >= 6 ) {
                    systolicMin = 85;
                    systolicMax = 105;
                } else if( age >= 3 ) {
                    systolicMin = 80;
                    systolicMax = 100;
                } else if( age >= 1 ) {
                    systolicMin = 75;
                    systolicMax = 95;
                } else if( age >= 6 / 12 ) {
                    systolicMin = 70;
                    systolicMax = 90;
                } else if( age >= 1 / 12 ) {
                    systolicMin = 65;
                    systolicMax = 85;
                } else {
                    systolicMin = 60;
                    systolicMax = 75;
                }
            }
        }
    } );

    // Cardiovascular
    mw.calculators.addCalculations( {
        vO2: {
            name: 'VO<sub>2</sub>',
            abbreviation: 'VO<sub>2</sub>',
            data: {
                calculations: {
                    required: [ 'bsa' ]
                },
                variables: {
                    optional: [ 'age' ]
                }
            },
            units: 'mL/min',
            references: [],
            calculate: function( data ) {
                var bsa = data.bsa.toNumber();
                var age = data.age ? data.age.toNumber( 'yr' ) : null;

                if( age >= 70 ) {
                    return 110 * bsa;
                } else {
                    return 125 * bsa;
                }
            }
        },
        cardiacOutputFick: {
            name: 'Cardiac output (Fick)',
            abbreviation: 'CO (Fick)',
            data: {
                variables: {
                    required: [ 'saO2', 'smvO2', 'hgb' ]
                },
                calculations: {
                    required: [ 'vO2' ]
                }
            },
            units: 'L/min',
            formula: '<math>\\mathrm{CO_{Fick}}=\\frac{VO_2}{(S_aO_2 - S_{mv}O_2) * H_b * 13.4}</math>',
            link: false,
            references: [],
            calculate: function( data ) {
                var vO2 = data.vO2.toNumber( 'mL/min' );
                var saO2 = data.saO2.toNumber() / 100;
                var smvO2 = data.smvO2.toNumber() / 100;
                var hgb = data.hgb.toNumber( 'ghgbperdL' );

                return vO2 / ( ( saO2 - smvO2 ) * hgb * 13.4 );
            }
        },
        cardiacIndex: {
            name: 'Cardiac index',
            abbreviation: 'CI',
            data: {
                calculations: {
                    required: [ 'bsa', 'cardiacOutputFick' ]
                }
            },
            units: 'L/min/m^2',
            formula: '<math>\\mathrm{CI}=\\frac{\\mathrm{CO}}{\\mathrm{BSA}}</math>',
            link: false,
            references: [],
            calculate: function( data ) {
                var cardiacOutput = data.cardiacOutputFick.toNumber( 'L/min' );
                var bsa = data.bsa.toNumber( 'm^2' );

                return cardiacOutput / bsa;
            }
        },
        strokeVolume: {
            name: 'Stroke volume',
            abbreviation: 'SV',
            data: {
                variables: {
                    required: [ 'heartRate' ]
                },
                calculations: {
                    required: [ 'cardiacOutputFick' ]
                }
            },
            units: 'mL',
            formula: '<math>\\mathrm{SV}=\\frac{\\mathrm{CO}}{\\mathrm{HR}}</math>',
            link: false,
            references: [],
            calculate: function( data ) {
                var cardiacOutput = data.cardiacOutputFick.toNumber( 'mL/min' );
                var heartRate = data.heartRate.toNumber();

                return cardiacOutput / heartRate;
            }
        }
    } );

    // Neuro
    mw.calculators.addCalculations( {
        brainMass: {
            name: 'Brain mass',
            data: {
                variables: {
                    optional: [ 'age', 'gender' ]
                }
            },
            digits: 0,
            units: 'gwt',
            references: [
                'Dekaban AS. Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann Neurol. 1978 Oct;4(4):345-56. doi: 10.1002/ana.410040410. PMID: 727739.'
            ],
            calculate: function( data ) {
                var age = data.age ? data.age.toNumber( 'yr' ) : null;
                var gender = data.gender ? data.gender : null;

                var brainMassFemale = 1290;
                var brainMassMale = 1450;

                if( age !== null ) {
                    if( age <= 10 / 365 ) {
                        // <=10 days
                        brainMassFemale = 360;
                        brainMassMale = 380;
                    } else if( age <= 4 * 30 / 365 ) {
                        // Less than 4 months. This is a gap in the reported data of the paper, so linearly interpolate?
                        var ageFactor = 1 - ( 4 * 30 / 365 - age ) / ( 4 * 30 / 365 - 10 / 365 );

                        brainMassFemale = 360 + ageFactor * ( 580 - 360 );
                        brainMassMale = 380 + ageFactor * ( 640 - 380 );
                    } else if( age <= 8 * 30 / 365 ) {
                        // <=8 months
                        brainMassFemale = 580;
                        brainMassMale = 640;
                    } else if( age <= 18 * 30 / 365 ) {
                        // <=18 months
                        brainMassFemale = 940;
                        brainMassMale = 970;
                    } else if( age <= 30 * 30 / 365 ) {
                        // <=30 months
                        brainMassFemale = 1040;
                        brainMassMale = 1120;
                    } else if( age <= 43 * 30 / 365 ) {
                        // <=43 months
                        brainMassFemale = 1090;
                        brainMassMale = 1270;
                    } else if( age <= 5 ) {
                        brainMassFemale = 1150;
                        brainMassMale = 1300;
                    } else if( age <= 7 ) {
                        brainMassFemale = 1210;
                        brainMassMale = 1330;
                    } else if( age <= 9 ) {
                        brainMassFemale = 1180;
                        brainMassMale = 1370;
                    } else if( age <= 12 ) {
                        brainMassFemale = 1260;
                        brainMassMale = 1440;
                    } else if( age <= 15 ) {
                        brainMassFemale = 1280;
                        brainMassMale = 1410;
                    } else if( age <= 18 ) {
                        brainMassFemale = 1340;
                        brainMassMale = 1440;
                    } else if( age <= 21 ) {
                        brainMassFemale = 1310;
                        brainMassMale = 1450;
                    } else if( age <= 30 ) {
                        brainMassFemale = 1300;
                        brainMassMale = 1440;
                    } else if( age <= 40 ) {
                        brainMassFemale = 1290;
                        brainMassMale = 1440;
                    } else if( age <= 50 ) {
                        brainMassFemale = 1290;
                        brainMassMale = 1430;
                    } else if( age <= 55 ) {
                        brainMassFemale = 1280;
                        brainMassMale = 1410;
                    } else if( age <= 60 ) {
                        brainMassFemale = 1250;
                        brainMassMale = 1370;
                    } else if( age <= 65 ) {
                        brainMassFemale = 1240;
                        brainMassMale = 1370;
                    } else if( age <= 70 ) {
                        brainMassFemale = 1240;
                        brainMassMale = 1360;
                    } else if( age <= 75 ) {
                        brainMassFemale = 1230;
                        brainMassMale = 1350;
                    } else if( age <= 80 ) {
                        brainMassFemale = 1190;
                        brainMassMale = 1330;
                    } else if( age <= 85 ) {
                        brainMassFemale = 1170;
                        brainMassMale = 1310;
                    } else {
                        brainMassFemale = 1140;
                        brainMassMale = 1290;
                    }
                }

                if( gender === 'F' ) {
                    return brainMassFemale;
                } else if( gender === 'M' ) {
                    return brainMassMale;
                } else {
                    return ( brainMassFemale + brainMassMale ) / 2;
                }
            }
        },
        cerebralBloodVolume: {
            name: 'Cerebral blood volume',
            abbreviation: 'CBV',
            data: {
                calculations: {
                    required: [ 'brainMass' ]
                }
            },
            units: 'mL',
            description: '4 mL per 100g of brain mass',
            references: [
                'Tameem A, Krovvidi H, Cerebral physiology, Continuing Education in Anaesthesia Critical Care & Pain, Volume 13, Issue 4, August 2013, Pages 113–118, https://doi.org/10.1093/bjaceaccp/mkt001'
            ],
            calculate: function( data ) {
                var brainMass = data.brainMass.toNumber( 'gwt' );

                return 4 * brainMass / 100;
            }
        },
        cerebralBloodFlow: {
            name: 'Cerebral blood flow',
            abbreviation: 'CBF',
            data: {
                calculations: {
                    required: [ 'brainMass' ]
                },
                variables: {
                    optional: [ 'paCO2' ]
                }
            },
            units: 'mL/min',
            description: '50 mL/min per 100g of brain mass. Every mmHg in PaCO2 changes CBF by 1.5 mL/min per 100g of brain mass.',
            references: [
                'Tameem A, Krovvidi H, Cerebral physiology, Continuing Education in Anaesthesia Critical Care & Pain, Volume 13, Issue 4, August 2013, Pages 113–118, https://doi.org/10.1093/bjaceaccp/mkt001',
                'Brian JE Jr. Carbon dioxide and the cerebral circulation. Anesthesiology. 1998 May;88(5):1365-86. doi: 10.1097/00000542-199805000-00029. PMID: 9605698.'
            ],
            calculate: function( data ) {
                var brainMass = data.brainMass.toNumber( 'gwt' );
                var paCO2 = data.paCO2.toNumber( 'mmHg' );

                var cerebralBloodFlow = 50 * brainMass / 100;

                if( paCO2 ) {
                    // CO2 reductions don't reduce CBF more than 50%
                    var minCerebralBloodFlow = cerebralBloodFlow / 2;

                    cerebralBloodFlow += 1.5 * brainMass / 100 * ( paCO2 - 40 );

                    cerebralBloodFlow = math.max( cerebralBloodFlow, minCerebralBloodFlow );
                }

                return cerebralBloodFlow;
            }
        },
        cerebralMetabolicRateO2: {
            name: 'Cerebral metabolic rate (O<sub>2</sub>)',
            abbreviation: 'CMRO<sub>2</sub>',
            data: {
                calculations: {
                    required: [ 'brainMass' ]
                }
            },
            units: 'mL/min',
            description: '3 mL O<sub>2</sub>/min per 100g of brain mass',
            references: [
                'Tameem A, Krovvidi H, Cerebral physiology, Continuing Education in Anaesthesia Critical Care & Pain, Volume 13, Issue 4, August 2013, Pages 113–118, https://doi.org/10.1093/bjaceaccp/mkt001'
            ],
            calculate: function( data ) {
                var brainMass = data.brainMass.toNumber( 'gwt' );

                return 3 * brainMass / 100;
            }
        },
        cerebralMetabolicRateGlucose: {
            name: 'Cerebral metabolic rate (Glucose)',
            abbreviation: 'CMR<sub>glu</sub>',
            data: {
                calculations: {
                    required: [ 'brainMass' ]
                }
            },
            units: 'mg/min',
            description: '5 mg glucose/min per 100g of brain mass',
            references: [
                'Tameem A, Krovvidi H, Cerebral physiology, Continuing Education in Anaesthesia Critical Care & Pain, Volume 13, Issue 4, August 2013, Pages 113–118, https://doi.org/10.1093/bjaceaccp/mkt001'
            ],
            calculate: function( data ) {
                var brainMass = data.brainMass.toNumber( 'gwt' );

                return 5 * brainMass / 100;
            }
        }
    } );

    var tableMaxWidth = 600;

    mw.calculators.addCalculators( moduleId, {
        anatomy: {
            name: 'Patient statistics',
            calculations: [
                'bmi',
                'bsa',
                'ibw',
                'lbw'
            ],
            css: {
                'max-width': tableMaxWidth
            },
            table: true
        },
        fluidManagement: {
            name: 'Fluid management',
            calculations: [
                'fluidMaintenanceRate',
                'intraopFluids',
                'ebv',
                'maxAbl',
                'minUop'
            ],
            css: {
                'max-width': tableMaxWidth
            },
            table: true
        },
        cardiovascular: {
            name: 'Cardiovascular',
            calculations: [
                'vO2',
                'cardiacOutputFick',
                'cardiacIndex',
                'strokeVolume'
            ],
            css: {
                'max-width': tableMaxWidth
            },
            table: true
        },
        neuro: {
            name: 'Neuro',
            calculations: [
                'brainMass',
                'cerebralBloodVolume',
                'cerebralBloodFlow',
                'cerebralMetabolicRateO2',
                'cerebralMetabolicRateGlucose'
            ],
            css: {
                'max-width': tableMaxWidth
            },
            table: true
        }
    } );
}() );