Difference between revisions of "Propofol"
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Chris Rishel (talk | contribs) Tag: 2017 source edit |
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| contraindications = Egg/soy allergy (controversial) | | contraindications = Egg/soy allergy (controversial) | ||
| routes = Intravenous | | routes = Intravenous | ||
| | | dosage_calculation = propofol | ||
| mechanism = GABA agonism | | mechanism = GABA agonism | ||
| adverse_effects = Hypotension | | adverse_effects = Hypotension | ||
Bradycardia | |||
Pain on injection | |||
| time_onset = 15-30 seconds | | time_onset = 15-30 seconds | ||
| duration = 5-10 minutes | | duration = 5-10 minutes | ||
| Line 27: | Line 22: | ||
| protein_binding = 95-99% | | protein_binding = 95-99% | ||
| pka = 11 | | pka = 11 | ||
}}Provide a brief summary of this drug here. | | volume_distribution = 6-40 L (central) | ||
150-700 L (steady state) | |||
| formula = C<sub>12</sub>H<sub>18</sub>O | |||
| molar_mass = 178.275 g/mol | |||
}}Provide a brief summary of this drug here. Test. Another test. Yet another test. Wo | |||
==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ||
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====Adverse effects<!-- Describe any potential adverse effects of the drug. -->==== | ====Adverse effects<!-- Describe any potential adverse effects of the drug. -->==== | ||
[[File:Hilton Worldwide logo.svg|thumb]] | |||
===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->=== | ===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->=== | ||
Latest revision as of 23:43, 29 March 2022
Propofol
| Trade names |
Diprivan |
|---|---|
 | |
| Clinical data | |
| Drug class |
Sedative hypnotic |
| Uses |
Induction and maintenance of anesthesia, sedation |
| Contraindications |
Egg/soy allergy (controversial) |
| Routes of administration |
Intravenous |
| Dosage | |
| Pharmacodynamics | |
| Mechanism of action |
GABA agonism |
| Adverse effects |
Hypotension Bradycardia Pain on injection |
| Pharmacokinetics | |
| Onset of action |
15-30 seconds |
| Duration of action |
5-10 minutes |
| Metabolism |
Liver glucuronidation |
| Redistribution half-life |
2-8 minutes (initial) 30-70 minutes (slow) |
| Elimination half-life |
1.5-31 hours |
| Clearance |
1.5-2.2 L/min |
| Protein binding |
95-99% |
| pKa |
11 |
| Volume of distribution |
6-40 L (central) 150-700 L (steady state) |
| Physical and chemical data | |
| Formula |
C12H18O |
| Molar mass |
178.275 g/mol |
| Article information | |
| Editor rating | |
| Likes | 0 |
| Top authors | |
| Chris Rishel, Barrett Larson and Test User 6 | |
Provide a brief summary of this drug here. Test. Another test. Yet another test. Wo
