Difference between revisions of "Propofol"
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Chris Rishel (talk | contribs) Tag: 2017 source edit |
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| contraindications = Egg/soy allergy (controversial) | | contraindications = Egg/soy allergy (controversial) | ||
| routes = Intravenous | | routes = Intravenous | ||
| | | dosage_calculation = propofol | ||
| mechanism = GABA agonism | | mechanism = GABA agonism | ||
| adverse_effects = Hypotension | | adverse_effects = Hypotension | ||
| Line 33: | Line 26: | ||
| formula = C<sub>12</sub>H<sub>18</sub>O | | formula = C<sub>12</sub>H<sub>18</sub>O | ||
| molar_mass = 178.275 g/mol | | molar_mass = 178.275 g/mol | ||
}}Provide a brief summary of this drug here. Test. Another test. Yet another test. | }}Provide a brief summary of this drug here. Test. Another test. Yet another test. Wo | ||
==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ||
Latest revision as of 23:43, 29 March 2022
Propofol
| Trade names |
Diprivan |
|---|---|
 | |
| Clinical data | |
| Drug class |
Sedative hypnotic |
| Uses |
Induction and maintenance of anesthesia, sedation |
| Contraindications |
Egg/soy allergy (controversial) |
| Routes of administration |
Intravenous |
| Dosage | |
| Pharmacodynamics | |
| Mechanism of action |
GABA agonism |
| Adverse effects |
Hypotension Bradycardia Pain on injection |
| Pharmacokinetics | |
| Onset of action |
15-30 seconds |
| Duration of action |
5-10 minutes |
| Metabolism |
Liver glucuronidation |
| Redistribution half-life |
2-8 minutes (initial) 30-70 minutes (slow) |
| Elimination half-life |
1.5-31 hours |
| Clearance |
1.5-2.2 L/min |
| Protein binding |
95-99% |
| pKa |
11 |
| Volume of distribution |
6-40 L (central) 150-700 L (steady state) |
| Physical and chemical data | |
| Formula |
C12H18O |
| Molar mass |
178.275 g/mol |
| Article information | |
| Editor rating | |
| Likes | 0 |
| Top authors | |
| Chris Rishel, Barrett Larson and Test User 6 | |
Provide a brief summary of this drug here. Test. Another test. Yet another test. Wo
Uses
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Adverse effects
Pharmacokinetics
Chemistry and formulation
History
References
Top contributors: Chris Rishel, Barrett Larson and Test User 6