Difference between revisions of "MediaWiki:Gadget-calculator-drugs-core.js"
From WikiAnesthesia
				| Chris Rishel (talk | contribs) | Chris Rishel (talk | contribs)  | ||
| Line 3: | Line 3: | ||
|   */ |   */ | ||
| ( function() { | ( function() { | ||
|      var  |      var DEFAULT_DRUG_COLOR = 'default'; | ||
|     var DEFAULT_DRUG_POPULATION = 'general'; | |||
|     var DEFAULT_DRUG_ROUTE = 'iv'; | |||
|      mw.calculators.isValueDependent = function( value, variableId ) { | |||
|          // This may need generalized to support other variables in the future | |||
|          if( variableId === 'weight' ) { | |||
|              return value && value.formatUnits().match( /\/[\s(]*?kg/ ); | |||
|         } else { | |||
|             throw new Error( 'Dependence "' + variableId + '" not supported by isValueDependent' ); | |||
|          } |          } | ||
|      }; |      }; | ||
|     /** | |||
|      * Define units | |||
|      */ | |||
|     mw.calculators.addUnitsBases( { | |||
|         concentration: { | |||
|             toString: function( units ) { | |||
|                 units = units.replace( ' pct', '%' ); | |||
|                 units = units.replace( 'ug', 'mcg' ); | |||
|                 return units; | |||
|              } |              } | ||
|          }, |          }, | ||
|          mass: { | |||
|              toString: function( units ) { | |||
|                  units = units.replace( 'ug', 'mcg' ); | |||
|                 return units; | |||
|              } |              } | ||
|         } | |||
|     } ); | |||
|     mw.calculators.addUnits( { | |||
|         mcg: { | |||
|              baseName: 'mass', | |||
|              definition: '1 ug' | |||
|          }, |          }, | ||
|          pct: { | |||
|              baseName: 'concentration', | |||
|              definition: '10 mg/mL' | |||
|          }, |          }, | ||
|          vial: { | |||
|              baseName: 'volume' | |||
|         } | |||
|     } ); | |||
|     /** | |||
|      * DrugColor | |||
|      */ | |||
|     mw.calculators.drugColors = {}; | |||
|     mw.calculators.addDrugColors = function( drugColorData ) { | |||
|         var drugColors = mw.calculators.createCalculatorObjects( 'DrugColor', drugColorData ); | |||
|         for( var drugColorId in drugColors ) { | |||
|             mw.calculators.drugColors[ drugColorId ] = drugColors[ drugColorId ]; | |||
|         } | |||
|     }; | |||
|     mw.calculators.getDrugColor = function( drugColorId ) { | |||
|         if( mw.calculators.drugColors.hasOwnProperty( drugColorId ) ) { | |||
|             return mw.calculators.drugColors[ drugColorId ]; | |||
|         } else { | |||
|             return null; | |||
|         } | |||
|     }; | |||
|     /** | |||
|      * Class DrugColor | |||
|      * @param {Object} propertyValues | |||
|      * @returns {mw.calculators.objectClasses.DrugColor} | |||
|      * @constructor | |||
|      */ | |||
|     mw.calculators.objectClasses.DrugColor = function( propertyValues ) { | |||
|         var properties = { | |||
|             required: [ | |||
|                  'id' | |||
|              ], | |||
|             optional: [ | |||
|                 'parentColor', | |||
|                 'primaryColor', | |||
|                  'highlightColor', | |||
|                 'striped' | |||
|              } |              ] | ||
|         }; | |||
|         mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues ); | |||
|         this.parentColor = this.parentColor || this.id === DEFAULT_DRUG_COLOR ? this.parentColor : DEFAULT_DRUG_COLOR; | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugColor.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype ); | |||
|     mw.calculators.objectClasses.DrugColor.prototype.getParentDrugColor = function() { | |||
|         if( !this.parentColor ) { | |||
|             return null; | |||
|         } | |||
|          var parentDrugColor = mw.calculators.getDrugColor( this.parentColor ); | |||
|         if( !parentDrugColor ) { | |||
|              throw new Error( 'Parent drug color "' + this.parentColor + '" not found for drug color "' + this.id + '"' ); | |||
|         } | |||
|         return parentDrugColor; | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugColor.prototype.getHighlightColor = function() { | |||
|         if( this.highlightColor ) { | |||
|              return this.highlightColor; | |||
|         } else if( this.parentColor ) { | |||
|             return this.getParentDrugColor().getHighlightColor(); | |||
|         } | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugColor.prototype.getPrimaryColor = function() { | |||
|         if( this.primaryColor ) { | |||
|             return this.primaryColor; | |||
|         } else if( this.parentColor ) { | |||
|             return this.getParentDrugColor().getPrimaryColor(); | |||
|         } | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugColor.prototype.isStriped = function() { | |||
|              } |         if( this.striped !== null ) { | ||
|             return this.striped; | |||
|         } else if( this.parentColor ) { | |||
|              return this.getParentDrugColor().isStriped(); | |||
|         } | |||
|     }; | |||
|     /** | |||
|      * DrugPopulation | |||
|      */ | |||
|     mw.calculators.drugPopulations = {}; | |||
|     mw.calculators.addDrugPopulations = function( drugPopulationData ) { | |||
|         var drugPopulations = mw.calculators.createCalculatorObjects( 'DrugPopulation', drugPopulationData ); | |||
|         for( var drugPopulationId in drugPopulations ) { | |||
|              mw.calculators.drugPopulations[ drugPopulationId ] = drugPopulations[ drugPopulationId ]; | |||
|         } | |||
|     }; | |||
|     mw.calculators.getDrugPopulation = function( drugPopulationId ) { | |||
|         if( mw.calculators.drugPopulations.hasOwnProperty( drugPopulationId ) ) { | |||
|             return mw.calculators.drugPopulations[ drugPopulationId ]; | |||
|         } else { | |||
|              return null; | |||
|         } | |||
|     }; | |||
|     /** | |||
|      * Class DrugPopulation | |||
|      * @param {Object} propertyValues | |||
|      * @returns {mw.calculators.objectClasses.DrugPopulation} | |||
|      * @constructor | |||
|      */ | |||
|     mw.calculators.objectClasses.DrugPopulation = function( propertyValues ) { | |||
|         var properties = { | |||
|              required: [ | |||
|                  'id', | |||
|                 'name' | |||
|             ], | |||
|             optional: [ | |||
|                  'abbreviation', | |||
|                 'variables' | |||
|             ] | |||
|         }; | |||
|         mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues ); | |||
|         if( this.variables ) { | |||
|             for( var variableId in this.variables ) { | |||
|                 if( !mw.calculators.getVariable( variableId ) ) { | |||
|                      throw new Error( 'DrugPopulation variable "' + variableId + '" not defined' ); | |||
|                  } |                  } | ||
|                 this.variables[ variableId ].min = this.variables[ variableId ].hasOwnProperty( 'min' ) ? | |||
|                     math.unit( this.variables[ variableId ].min ) : null; | |||
|                 this.variables[ variableId ].max = this.variables[ variableId ].hasOwnProperty( 'max' ) ? | |||
|                     math.unit( this.variables[ variableId ].max ) : null; | |||
|              } |              } | ||
|         } else { | |||
|             this.variables = {}; | |||
|         } | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugPopulation.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype ); | |||
|     mw.calculators.objectClasses.DrugPopulation.prototype.getCalculationData = function() { | |||
|         var inputData = new mw.calculators.objectClasses.CalculationData(); | |||
|          for( var variableId in this.variables ) { | |||
|              inputData.variables.required.push( variableId ); | |||
|         } | |||
|         return inputData; | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugPopulation.prototype.getCalculationDataScore = function( dataValues ) { | |||
|         // A return value of -1 indicates the data did not match the population definition | |||
|         for( var variableId in this.variables ) { | |||
|              if( !dataValues.hasOwnProperty( variableId ) ) { | |||
|                 return -1; | |||
|              } |              } | ||
|              if( this.variables[ variableId ].min && | |||
|                 ( !dataValues[ variableId ] || | |||
|                     !math.largerEq( dataValues[ variableId ], this.variables[ variableId ].min ) ) ) { | |||
|                  return -1; | |||
|                  return  | |||
|              } |              } | ||
|              if( this.variables[ variableId ].max && | |||
|                 ( !dataValues[ variableId ] || | |||
|                     !math.smallerEq( dataValues[ variableId ], this.variables[ variableId ].max ) ) ) { | |||
|                 return -1; | |||
|              } | |||
|         } | |||
|         // If the data matches the population definition, the score corresponds to the number of variables in the | |||
|         // population definition. This should roughly correspond to the specificity of the population. | |||
|         return Object.keys( this.variables ).length; | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugPopulation.prototype.toString = function() { | |||
|         return mw.calculators.isMobile() && this.abbreviation ? this.abbreviation : this.name; | |||
|     }; | |||
|     /** | |||
|      * DrugRoute | |||
|      */ | |||
|     mw.calculators.drugRoutes = {}; | |||
|     mw.calculators.addDrugRoutes = function( drugRouteData ) { | |||
|         var drugRoutes = mw.calculators.createCalculatorObjects( 'DrugRoute', drugRouteData ); | |||
|         for( var drugRouteId in drugRoutes ) { | |||
|             mw.calculators.drugRoutes[ drugRouteId ] = drugRoutes[ drugRouteId ]; | |||
|         } | |||
|     }; | |||
|     mw.calculators.getDrugRoute = function( drugRouteId ) { | |||
|          if( mw.calculators.drugRoutes.hasOwnProperty( drugRouteId ) ) { | |||
|             return mw.calculators.drugRoutes[ drugRouteId ]; | |||
|          } else { | |||
|              return null; | |||
|          } | |||
|              return  | |||
|          } |          } | ||
|      }; |      }; | ||
|      /** |      /** | ||
|       * Class  |       * Class DrugRoute | ||
|       * @param {Object} propertyValues |       * @param {Object} propertyValues | ||
|       * @returns {mw.calculators.objectClasses. |       * @returns {mw.calculators.objectClasses.DrugRoute} | ||
|       * @constructor |       * @constructor | ||
|       */ |       */ | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugRoute = function( propertyValues ) { | ||
|          var properties = { | |||
|             required: [ | |||
|                 'id', | |||
|                 'name' | |||
|             ], | |||
|             optional: [ | |||
|                 'abbreviation', | |||
|                 'default' | |||
|             ] | |||
|         }; | |||
|          mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues ); | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugRoute.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype ); | |||
|     mw.calculators.objectClasses.DrugRoute.prototype.toString = function() { | |||
|         return mw.calculators.isMobile() && this.abbreviation ? this.abbreviation : this.name; | |||
|     }; | |||
|     /** | |||
|      * DrugIndication | |||
|      */ | |||
|     mw.calculators.drugIndications = {}; | |||
|     mw.calculators.addDrugIndications = function( drugIndicationData ) { | |||
|         var drugIndications = mw.calculators.createCalculatorObjects( 'DrugIndication', drugIndicationData ); | |||
|         for( var drugIndicationId in drugIndications ) { | |||
|             mw.calculators.drugIndications[ drugIndicationId ] = drugIndications[ drugIndicationId ]; | |||
|          } |          } | ||
|      }; |      }; | ||
|      mw.calculators. |      mw.calculators.getDrugIndication = function( drugIndicationId ) { | ||
|          if( mw.calculators.drugIndications.hasOwnProperty( drugIndicationId ) ) { | |||
|              return mw.calculators.drugIndications[ drugIndicationId ]; | |||
|         } else { | |||
|          } |              return null; | ||
|          } | |||
|      }; |      }; | ||
|      /** |      /** | ||
|       * Class  |       * Class DrugIndication | ||
|       * @param {Object} propertyValues |       * @param {Object} propertyValues | ||
|       * @returns {mw.calculators.objectClasses. |       * @returns {mw.calculators.objectClasses.DrugIndication} | ||
|       * @constructor |       * @constructor | ||
|       */ |       */ | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugIndication = function( propertyValues ) { | ||
|          var properties = { |          var properties = { | ||
|              required: [ |              required: [ | ||
|                  'id' |                  'id', | ||
|                 'name' | |||
|              ], |              ], | ||
|              optional: [ |              optional: [ | ||
|                  ' |                  'abbreviation', | ||
|                 'default' | |||
|              ] |              ] | ||
|          }; |          }; | ||
| Line 478: | Line 343: | ||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugIndication.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype ); | ||
|     mw.calculators.objectClasses.DrugIndication.prototype.toString = function() { | |||
|         return mw.calculators.isMobile() && this.abbreviation ? this.abbreviation : this.name; | |||
|     }; | |||
| Line 484: | Line 354: | ||
|      /** |      /** | ||
|       *  |       * Drug | ||
|       */ |       */ | ||
|      mw.calculators. |      mw.calculators.drugs = {}; | ||
|          var  | |||
|     mw.calculators.addDrugs = function( drugData ) { | |||
|          var drugs = mw.calculators.createCalculatorObjects( 'Drug', drugData ); | |||
|         for( var drugId in drugs ) { | |||
|              mw.calculators.drugs[ drugId ] = drugs[ drugId ]; | |||
|                  ' |             var drugDosageCalculationId = mw.calculators.getDrugDosageCalculationId( drugId ); | ||
|             var drugDosageCalculation = mw.calculators.getCalculation( drugDosageCalculationId ); | |||
|             if( !drugDosageCalculation ) { | |||
|                  var calculationData = {}; | |||
|                 calculationData[ drugDosageCalculationId ] = { | |||
|                     calculate: mw.calculators.objectClasses.DrugDosageCalculation.prototype.calculate, | |||
|                     drug: drugId, | |||
|                     type: 'drug' | |||
|                  }; | |||
|                  mw.calculators.addCalculations( calculationData, 'DrugDosageCalculation' ); | |||
|                  drugDosageCalculation = mw.calculators.getCalculation( drugDosageCalculationId ); | |||
|              } | |||
|             drugDosageCalculation.setDependencies(); | |||
|         } | |||
|      }; |      }; | ||
|      mw.calculators. |      mw.calculators.addDrugDosages = function( drugId, drugDosageData ) { | ||
|         var drug = mw.calculators.getDrug( drugId ); | |||
|         if( !drug ) { | |||
|             throw new Error( 'DrugDosage references drug "' + drugId + '" which is not defined' ); | |||
|         } | |||
|         drug.addDosages( drugDosageData ); | |||
|         // Update calculation dependencies | |||
|         var drugDosageCalculation = mw.calculators.getCalculation( mw.calculators.getDrugDosageCalculationId( drugId ) ); | |||
|         drugDosageCalculation.updateVariables(); | |||
|         drugDosageCalculation.setDependencies(); | |||
|     }; | |||
|     mw.calculators.getDrug = function( drugId ) { | |||
|         if( mw.calculators.drugs.hasOwnProperty( drugId ) ) { | |||
|             return mw.calculators.drugs[ drugId ]; | |||
|         } else { | |||
|             return null; | |||
|         } | |||
|     }; | |||
|      /** |      /** | ||
|       * Class  |       * Class Drug | ||
|       * @param {Object} propertyValues |       * @param {Object} propertyValues | ||
|       * @returns {mw.calculators.objectClasses. |       * @returns {mw.calculators.objectClasses.Drug} | ||
|       * @constructor |       * @constructor | ||
|       */ |       */ | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.Drug = function( propertyValues ) { | ||
|          mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues ); |          mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues ); | ||
|          if(  |          if( !this.color ) { | ||
|              this.color = DEFAULT_DRUG_COLOR; | |||
|          } |          } | ||
|          var color = mw.calculators.getDrugColor( this.color ); | |||
|         if( !color ) { | |||
|              throw new Error( 'Invalid drug color "' + this.color + '" for drug "' + this.id + '"' ); | |||
|         } | |||
|         this.color = color; | |||
|         if( this.preparations ) { | |||
|             var preparationData = this.preparations; | |||
|              this.preparations = []; | |||
|              this. |              this.addPreparations( preparationData ); | ||
|         } else { | |||
|             this.preparations = []; | |||
|          } |          } | ||
|          this. |          if( this.dosages ) { | ||
|             var dosageData = this.dosages; | |||
|             this.dosages = []; | |||
|              this. | |||
|             this.addDosages( dosageData ); | |||
|         } else { | |||
|              this.dosages = []; | |||
|          } |          } | ||
|     }; | |||
|     mw.calculators.objectClasses.Drug.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype ); | |||
|     mw.calculators.objectClasses.Drug.prototype.addDosages = function( dosageData ) { | |||
|         var dosages = mw.calculators.createCalculatorObjects( 'DrugDosage', dosageData ); | |||
|         for( var dosageId in dosages ) { | |||
|             dosages[ dosageId ].id = this.dosages.length; | |||
|             this.dosages.push( dosages[ dosageId ] ); | |||
|         } | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.Drug.prototype.addPreparations = function( preparationData ) { | ||
|         var preparations = mw.calculators.createCalculatorObjects( 'DrugPreparation', preparationData ); | |||
|         for( var preparationId in preparations ) { | |||
|             preparations[ preparationId ].id = this.preparations.length; | |||
|             this.preparations.push( preparations[ preparationId ] ); | |||
|          } |          } | ||
|     }; | |||
|     mw.calculators.objectClasses.Drug.prototype.getIndications = function() { | |||
|         var indications = []; | |||
|         for( var iDosage in this.dosages ) { | |||
|             if( this.dosages[ iDosage ].indication ) { | |||
|                 indications.push( this.dosages[ iDosage ].indication ); | |||
|              } | |||
|          } |          } | ||
|          return indications.filter( mw.calculators.uniqueValues ); | |||
|     }; | |||
|     mw.calculators.objectClasses.Drug.prototype.getPopulations = function( indicationId ) { | |||
|          var populations = []; | |||
|          var  |          for( var iDosage in this.dosages ) { | ||
|             if( this.dosages[ iDosage ].population && | |||
|                 ( !indicationId || ( this.dosages[ iDosage ].indication && this.dosages[ iDosage ].indication.id === indicationId ) ) ) { | |||
|                 populations.push( this.dosages[ iDosage ].population ); | |||
|             } | |||
|          } | |||
|          return populations.filter( mw.calculators.uniqueValues ); | |||
|     }; | |||
|     mw.calculators.objectClasses.Drug.prototype.getRoutes = function( indicationId ) { | |||
|          var routes = []; | |||
|          for( var iDosage in this.dosages ) { | |||
|             if( this.dosages[ iDosage ].route && | |||
|                 ( !indicationId || ( this.dosages[ iDosage ].indication && this.dosages[ iDosage ].indication.id === indicationId ) ) ) { | |||
|                 routes.push( this.dosages[ iDosage ].route ); | |||
|             } | |||
|          } | |||
|          return routes.filter( mw.calculators.uniqueValues ); | |||
|     }; | |||
|     mw.calculators.objectClasses.Drug.prototype.getPreparations = function( excludeDilutionRequired ) { | |||
|          var  |          var preparations = this.preparations.filter( mw.calculators.uniqueValues ); | ||
|          if(  |          if( excludeDilutionRequired ) { | ||
|             for( var iPreparation in preparations ) { | |||
|                 if( preparations[ iPreparation ].dilutionRequired ) { | |||
|                     delete preparations[ iPreparation ]; | |||
|                 } | |||
|              } | |||
|          } |          } | ||
|          return preparations; | |||
|     }; | |||
|     mw.calculators.objectClasses.Drug.prototype.getProperties = function() { | |||
|         return { | |||
|             required: [ | |||
|                 'id', | |||
|                 'name' | |||
|              ], | |||
|             optional: [ | |||
|                 'color', | |||
|                 'dosages', | |||
|                 'preparations' | |||
|             ] | |||
|         }; | |||
|     }; | |||
|     /** | |||
|      * DrugPreparation | |||
|      */ | |||
|     mw.calculators.addDrugPreparations = function( drugId, drugPreparationData ) { | |||
|          var drug = mw.calculators.getDrug( drugId ); | |||
|          if( !drug ) { | |||
|             throw new Error( 'DrugPreparation references drug "' + drugId + '" which is not defined' ); | |||
|         } | |||
|          drug.addPreparations( drugPreparationData ); | |||
|         var drugDosageCalculation = mw.calculators.getCalculation( mw.calculators.getDrugDosageCalculationId( drugId ) ); | |||
|         drugDosageCalculation.recalculate(); | |||
|     }; | |||
|     /** | |||
|      * Class DrugPreparation | |||
|      * @param {Object} propertyValues | |||
|              } |      * @returns {mw.calculators.objectClasses.DrugPreparation} | ||
|      * @constructor | |||
|      */ | |||
|     mw.calculators.objectClasses.DrugPreparation = function( propertyValues ) { | |||
|         var properties = { | |||
|             required: [ | |||
|                 'id', | |||
|                  'concentration' | |||
|             ], | |||
|             optional: [ | |||
|                 'default', | |||
|                 'dilutionRequired', | |||
|                 'commonDilution' | |||
|              ] | |||
|         }; | |||
|         mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues ); | |||
|         this.concentration = this.concentration.replace( 'mcg', 'ug' ); | |||
|         this.concentration = math.unit( this.concentration ); | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugPreparation.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype ); | |||
|     mw.calculators.objectClasses.DrugPreparation.prototype.getVolumeUnits = function() { | |||
|         // The units of concentration will always be of the form "mass / volume" | |||
|         // The regular expression matches all text leading up to the volume units | |||
|         return mw.calculators.getUnitsByBase( this.concentration ).volume; | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugPreparation.prototype.toString = function() { | |||
|         return mw.calculators.getValueString( this.concentration ); | |||
|     }; | |||
|     /** | |||
|      * Class DrugDosage | |||
|      * @param {Object} propertyValues | |||
|      * @returns {mw.calculators.objectClasses.DrugDosage} | |||
|      * @constructor | |||
|      */ | |||
|     mw.calculators.objectClasses.DrugDosage = function( propertyValues ) { | |||
|         mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues ); | |||
|         var drugIndication = mw.calculators.getDrugIndication( this.indication ); | |||
|         if( !drugIndication ) { | |||
|             throw new Error( 'Invalid indication "' + this.indication + '" for drug dosage' ); | |||
|         } | |||
|         this.indication = drugIndication; | |||
|         this.population = this.population ? this.population : DEFAULT_DRUG_POPULATION; | |||
|         var drugPopulation = mw.calculators.getDrugPopulation( this.population ); | |||
|         if( !drugPopulation ) { | |||
|             throw new Error( 'Invalid population "' + this.population + '" for drug dosage' ); | |||
|         } | |||
|         this.population = drugPopulation; | |||
|         this.route = this.route ? this.route : DEFAULT_DRUG_ROUTE; | |||
|         var drugRoute = mw.calculators.getDrugRoute( this.route ); | |||
|         if( !drugRoute ) { | |||
|             throw new Error( 'Invalid route "' + this.route + '" for drug dosage' ); | |||
|         } | |||
|         this.route = drugRoute; | |||
|         // Add the dose objects to the drug | |||
|         var drugDoseData = this.dose; | |||
|         this.dose = []; | |||
|         this.addDoses( drugDoseData ); | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugDosage.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype ); | |||
|     mw.calculators.objectClasses.DrugDosage.prototype.addDoses = function( drugDoseData ) { | |||
|         // Each dosage can have one or more associated doses. Ensure this value is an array. | |||
|         if( !Array.isArray( drugDoseData ) ) { | |||
|             drugDoseData = [ drugDoseData ]; | |||
|         } | |||
|         var doses = mw.calculators.createCalculatorObjects( 'DrugDose', drugDoseData ); | |||
|         for( var doseId in doses ) { | |||
|             doses[ doseId ].id = this.dose.length; | |||
|             this.dose.push( doses[ doseId ] ); | |||
|         } | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugDosage.prototype.getCalculationData = function() { | |||
|         var inputData = new mw.calculators.objectClasses.CalculationData(); | |||
|         inputData = inputData.merge( this.population.getCalculationData() ); | |||
|         for( var iDose in this.dose ) { | |||
|             inputData = inputData.merge( this.dose[ iDose ].getCalculationData() ); | |||
|          } |          } | ||
|          return  |          return inputData; | ||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosage.prototype.getProperties = function() { | ||
|          return { |          return { | ||
|              required: [ |              required: [ | ||
|                 'dose', | |||
|                  'id', |                  'id', | ||
|                  ' |                  'indication' | ||
|              ], |              ], | ||
|              optional: [ |              optional: [ | ||
|                  ' |                  'description', | ||
|                  ' |                  'population', | ||
|                  ' |                  'route' | ||
|              ] |              ] | ||
|          }; |          }; | ||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosage.prototype.hasInfo = function() { | ||
|          return this.description; | |||
|      }; |      }; | ||
|     /** | |||
|      * Class DrugDose | |||
|      * @param {Object} propertyValues | |||
|      * @returns {mw.calculators.objectClasses.DrugDose} | |||
|      * @constructor | |||
|      */ | |||
|     mw.calculators.objectClasses.DrugDose = function( propertyValues ) { | |||
|         mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues ); | |||
|          if( this.weightCalculation ) { | |||
|             var weightCalculationIds = this.weightCalculation; | |||
|             // weightCalculation property will contain references to the actual objects, so reinitialize | |||
|             this.weightCalculation = []; | |||
|              if( !Array.isArray( weightCalculationIds ) ) { | |||
|                  weightCalculationIds = [ weightCalculationIds ]; | |||
|              } |              } | ||
|              for( var iWeightCalculation in weightCalculationIds ) { | |||
|                  var  |                  var weightCalculationId = weightCalculationIds[ iWeightCalculation ]; | ||
|                 var weightCalculation = mw.calculators.getCalculation( weightCalculationId ); | |||
|                  if( ! |                  if( !weightCalculation ) { | ||
|                      throw new Error( ' |                      throw new Error( 'Drug dose references weight calculation "' + weightCalculationId + '" which is not defined' ); | ||
|                  } |                  } | ||
|                 this.weightCalculation.push( weightCalculation ); | |||
|              } |              } | ||
|          } else  |          } else { | ||
|              this.weightCalculation = []; | |||
|          } |          } | ||
|          var mathProperties = this.getMathProperties(); | |||
|         var isWeightDependent = false; | |||
|         for( var iMathProperty in mathProperties ) { | |||
|             var mathProperty = mathProperties[ iMathProperty ]; | |||
|             if( this[ mathProperty ] ) { | |||
|                 // TODO consider making a UnitsBase.weight.fromString() | |||
|                 this[ mathProperty ] = this[ mathProperty ].replace( 'kg', 'kgwt' ); | |||
|                 this[ mathProperty ] = this[ mathProperty ].replace( 'mcg', 'ug' ); | |||
|                 this[ mathProperty ] = math.unit( this[ mathProperty ] ); | |||
|                 if( mw.calculators.isValueDependent( this[ mathProperty ], 'weight' ) ) { | |||
|                      isWeightDependent = true; | |||
|                  } |                  } | ||
|             } else { | |||
|                 this[ mathProperty ] = null; | |||
|              } |              } | ||
|          } |          } | ||
|          if( isWeightDependent ) { | |||
|             // Default is tbw | |||
|             this.weightCalculation.push( mw.calculators.getCalculation( 'tbw' ) ); | |||
|         } | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDose.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype ); | ||
|     mw.calculators.objectClasses.DrugDose.prototype.getAdministration = function() { | |||
|         var administration = ''; | |||
|          if( this.frequency ) { | |||
|             administration += administration ? ' ' : ''; | |||
|             administration += this.frequency; | |||
|         } | |||
|          if( this.duration ) { | |||
|              administration += administration ? ' ' : ''; | |||
|              administration += 'over ' + this.duration; | |||
|          } |          } | ||
|          return administration; | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDose.prototype.getCalculationData = function() { | ||
|         var calculationData = new mw.calculators.objectClasses.CalculationData(); | |||
|         for( var iWeightCalculation in this.weightCalculation ) { | |||
|             calculationData.calculations.optional.push( this.weightCalculation[ iWeightCalculation ].id ); | |||
|          } |          } | ||
|          return calculationData; | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDose.prototype.getMathProperties = function() { | ||
|          return [ | |||
|             'dose', | |||
|          return ' |             'min', | ||
|             'max', | |||
|             'absoluteMax' | |||
|          ]; | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDose.prototype.getProperties = function() { | ||
|          return { |          return { | ||
|              required: [ |              required: [ | ||
|                  'id |                  'id' | ||
|              ], |              ], | ||
|              optional: [ |              optional: [ | ||
|                  ' |                  'absoluteMax', | ||
|                  ' |                  'dose', | ||
|                  ' |                  'duration', | ||
|                  ' |                  'frequency', | ||
|                  ' |                  'min', | ||
|                  ' |                  'max', | ||
|                 'name', | |||
|                 'weightCalculation' | |||
|              ] |              ] | ||
|          }; |          }; | ||
|      }; |      }; | ||
|          return  | |||
|     mw.calculators.getDrugDosageCalculationId = function( drugId ) { | |||
|          return 'drugDosages-' + drugId; | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      /** | ||
|      * Class DrugDosageCalculation | |||
|      * @param {Object} propertyValues | |||
|      * @returns {mw.calculators.objectClasses.DrugDosageCalculation} | |||
|      * @constructor | |||
|      */ | |||
|     mw.calculators.objectClasses.DrugDosageCalculation = function( propertyValues ) { | |||
|          mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues ); | |||
|         this.initialize(); | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosageCalculation.prototype = Object.create( mw.calculators.objectClasses.AbstractCalculation.prototype ); | ||
|     mw.calculators.objectClasses.DrugDosageCalculation.prototype.calculate = function( data ) { | |||
|          var value = { | |||
|             dosageId: null, | |||
|             message: null, | |||
|             population: null, | |||
|             preparation: data.preparation, | |||
|             dose: [] | |||
|         }; | |||
|         if( !data.drug.dosages.length ) { | |||
|             value.message = 'No dose data'; | |||
|             return value; | |||
|          } | |||
|          // Determine which dosage to use | |||
|          var  |          var populationScores = []; | ||
|          for( var  |          for( var iDosage in data.drug.dosages ) { | ||
|              var drugDosage = data.drug.dosages[ iDosage ]; | |||
|              // If the indication and route do not match, set the score to -1 | |||
|             var populationScore = | |||
|                  drugDosage.indication.id === data.indication.id && drugDosage.route.id === data.route.id ? | |||
|                  drugDosage.population.getCalculationDataScore( data ) : -1; | |||
|             populationScores.push( populationScore ); | |||
|          } |          } | ||
|          var maxPopulationScore = Math.max.apply( null, populationScores ); | |||
|         if( maxPopulationScore < 0 ) { | |||
|             value.message = 'No dose data for indication "' + String( data.indication ) + '" and route "' + String( data.route ) + '"'; | |||
|              return value; | |||
|          } |          } | ||
|          // If there is more than one dosage with the same score, take the first. | |||
|         // This allows the data editor to decide which is most important. | |||
|         value.dosageId = populationScores.indexOf( maxPopulationScore ); | |||
|         var dosage = data.drug.dosages[ value.dosageId ]; | |||
|         // A dosage may contain multiple doses (e.g. induction and maintenance) | |||
|         for( var iDose in dosage.dose ) { | |||
|             var dose = dosage.dose[ iDose ]; | |||
|              var mathProperties = dose.getMathProperties(); | |||
|             var weightCalculation = null; | |||
|             var weightValue = null; | |||
|             // data.weightCalculation should be in order of preference, so take the first non-null value | |||
|             for( var iWeightCalculation in dose.weightCalculation ) { | |||
|                 if( dose.weightCalculation[ iWeightCalculation ].value !== null ) { | |||
|                     weightCalculation = dose.weightCalculation[ iWeightCalculation ]; | |||
|                     weightValue = dose.weightCalculation[ iWeightCalculation ].value; | |||
|                     break; | |||
|                  } | |||
|              } |              } | ||
|              // Initialize value properties for dose | |||
|             value.dose[ iDose ] = { | |||
|                 massPerWeight: {}, | |||
|                 mass: {}, | |||
|                 volume: {}, | |||
|                 weightCalculation: weightCalculation ? weightCalculation : null | |||
|             }; | |||
|             var massUnits; | |||
|             var volumeUnits; | |||
|             for( var iMathProperty in mathProperties ) { | |||
|                 var mathProperty = mathProperties[ iMathProperty ]; | |||
|                 var doseValue = dose[ mathProperty ]; | |||
|                 if( doseValue ) { | |||
|                     var doseUnitsByBase = mw.calculators.getUnitsByBase( doseValue ); | |||
|                     if( doseUnitsByBase.hasOwnProperty( 'weight' ) ) { | |||
|                         value.dose[ iDose ].massPerWeight[ mathProperty ] = doseValue; | |||
|                         if( weightValue ) { | |||
|                             massUnits = doseUnitsByBase.mass; | |||
|                             if( doseUnitsByBase.hasOwnProperty( 'time' ) ) { | |||
|                                 massUnits += '/' + doseUnitsByBase.time; | |||
|                             } | |||
|                             // For whatever reason math.format will simplify the units, but math.formatUnits will not | |||
|                             // as a hack, we recreate a new unit value with the correct formatting of the result | |||
|                             value.dose[ iDose ].mass[ mathProperty ] = math.unit( math.multiply( doseValue, weightValue ).format() ).to( massUnits ); | |||
|                         } | |||
|                     } else { | |||
|                         value.dose[ iDose ].mass[ mathProperty ] = doseValue; | |||
|                     } | |||
|                     if( data.preparation && value.dose[ iDose ].mass[ mathProperty ] ) { | |||
|                         // Same hack as above to get units to simplify correctly | |||
|                         var preparationUnitsByBase = mw.calculators.getUnitsByBase( data.preparation.concentration ); | |||
|                         volumeUnits = preparationUnitsByBase.volume; | |||
|                         if( doseUnitsByBase.hasOwnProperty( 'time' ) ) { | |||
|                             volumeUnits += '/' + doseUnitsByBase.time; | |||
|                         } | |||
|                         value.dose[ iDose ].volume[ mathProperty ] = math.unit( math.multiply( value.dose[ iDose ].mass[ mathProperty ], math.divide( 1, data.preparation.concentration ) ).format() ).to( volumeUnits ); | |||
|                     } | |||
|                 } | |||
|             } | |||
|             if( value.dose[ iDose ].mass.hasOwnProperty( 'absoluteMax' ) ) { | |||
|                 if( value.dose[ iDose ].mass.hasOwnProperty( 'min' ) && math.smaller( value.dose[ iDose ].mass.absoluteMax, value.dose[ iDose ].mass.min ) ) { | |||
|                     // Both min and max are larger than the absolute max dose, so just convert to single dose. | |||
|                     value.dose[ iDose ].mass.dose = value.dose[ iDose ].mass.absoluteMax; | |||
|                     delete value.dose[ iDose ].mass.min; | |||
|                     delete value.dose[ iDose ].mass.max; | |||
|                     if( value.dose[ iDose ].volume.hasOwnProperty( 'absoluteMax' ) ) { | |||
|                         value.dose[ iDose ].volume.dose = value.dose[ iDose ].volume.absoluteMax; | |||
|                         delete value.dose[ iDose ].volume.min; | |||
|                         delete value.dose[ iDose ].volume.max; | |||
|                     } | |||
|                 } else if( value.dose[ iDose ].mass.hasOwnProperty( 'max' ) && math.smaller( value.dose[ iDose ].mass.absoluteMax, value.dose[ iDose ].mass.max ) ) { | |||
|                     value.dose[ iDose ].mass.max = value.dose[ iDose ].mass.absoluteMax; | |||
|                     if( value.dose[ iDose ].volume.hasOwnProperty( 'absoluteMax' ) ) { | |||
|                         value.dose[ iDose ].volume.max = value.dose[ iDose ].volume.absoluteMax; | |||
|                     } | |||
|                 } else if( value.dose[ iDose ].mass.hasOwnProperty( 'dose' ) && math.smaller( value.dose[ iDose ].mass.absoluteMax, value.dose[ iDose ].mass.dose ) ) { | |||
|                     value.dose[ iDose ].mass.dose = value.dose[ iDose ].mass.absoluteMax; | |||
|                     if( value.dose[ iDose ].volume.hasOwnProperty( 'absoluteMax' ) ) { | |||
|                         value.dose[ iDose ].volume.dose = value.dose[ iDose ].volume.absoluteMax; | |||
|                     } | |||
|                  } |                  } | ||
|              } |              } | ||
|          } |          } | ||
|          return  |          return value; | ||
|      }; |      }; | ||
|     mw.calculators.objectClasses.DrugDosageCalculation.prototype.doRender = function() { | |||
|         var $calculationContainer = $( '.' + this.getContainerClass() ); | |||
|         if( !$calculationContainer.length ) { | |||
|             return; | |||
|         } | |||
|         $calculationContainer.empty(); | |||
|         // Drug label | |||
|         var drugLabelAttributes = { | |||
|             class: 'calculator-DrugDosageCalculator-drug-cell' | |||
|          }; | |||
|          var $drugLabel = $( '<div>', drugLabelAttributes ); | |||
|          this. |          $drugLabel.append( this.getLabelHtml() ); | ||
|         // Dose column | |||
|         var $dose = $( '<div>', { | |||
|             class: 'col-8 calculator-DrugDosageCalculator-dose-cell' | |||
|          }  ); | |||
|          var  |          var dash = '-'; | ||
|          // The options column should only show the preparation if there is a calculated volume | |||
|         var hasVolume; | |||
|              if(  |         if( !this.value || this.value.dosageId === null ) { | ||
|              if( this.value && this.value.hasOwnProperty( 'message' ) ) { | |||
|                  $dose.append( $( '<i>' ).append( this.value.message ) ); | |||
|              } |              } | ||
|         } else { | |||
|             var dosage = this.drug.dosages[ this.value.dosageId ]; | |||
|              var showInfo; | |||
|             var $doseInfo = $( '<div>', { | |||
|                 class: 'calculator-DrugDosageCalculator-dose-info' | |||
|             } ); | |||
|             if( dosage.population && dosage.population.id !== DEFAULT_DRUG_POPULATION ) { | |||
|                 $doseInfo | |||
|                     .append( $( '<div>', { | |||
|                         class: 'calculator-DrugDosageCalculator-dose-info-population' | |||
|                     } ).append( String( dosage.population ) + ' dosing' ) ); | |||
|                  showInfo = true; | |||
|              } |              } | ||
|              mw.calculators. |              if( dosage.hasInfo() ) { | ||
|                 var doseInfoText = mw.calculators.isMobile() ? 'Dosage info' : 'Dosage information'; | |||
|                 var $doseInfoLink = $( '<a>', { | |||
|                     'data-toggle': 'collapse', | |||
|                     href: '#' + this.getContainerClass() + '-dose-info-row', | |||
|                     role: 'button', | |||
|                     'aria-expanded': 'false', | |||
|                     'aria-controls': this.getContainerClass() + '-dose-info-row' | |||
|                 } ) | |||
|                     .append( doseInfoText + ' ' ) | |||
|                     .append( $( '<i>', { | |||
|                         class: 'far fa-question-circle' | |||
|                     } ) ); | |||
|                 $doseInfo | |||
|                     .append( $( '<div>', { | |||
|                         class: 'calculator-DrugDosageCalculator-dose-info-button' | |||
|                     } ).append( $doseInfoLink ) ); | |||
|                 showInfo = true; | |||
|              } | |||
|              if(  |              if( showInfo ) { | ||
|                  $dose.append( $doseInfo ); | |||
|              } |              } | ||
|             var $doseData = $( '<div>', { | |||
|                 class: 'calculator-DrugDosageCalculator-dose-data' | |||
|             } ); | |||
|             // This will iterate through the calculated doses. iDose should exactly correspond to doses within dosage | |||
|             // to allow referencing other properties of the dose. | |||
|             for( var iDose in this.value.dose ) { | |||
|                 var dose = dosage.dose[ iDose ]; | |||
|                 var doseValue = this.value.dose[ iDose ]; | |||
|                 if( dose.name ) { | |||
|                     $doseData.append( dose.name + '<br />' ); | |||
|                 } | |||
|                 var $doseList = $( '<ul>' ); | |||
|                 var administration = dose.getAdministration(); | |||
|                 var administrationDisplayed = false; | |||
|                 var massPerWeightHtml = ''; | |||
|                 if( doseValue.massPerWeight.hasOwnProperty( 'dose' ) ) { | |||
|                     massPerWeightHtml += mw.calculators.getValueString( doseValue.massPerWeight.dose ); | |||
|                 } else if( doseValue.massPerWeight.hasOwnProperty( 'min' ) && | |||
|                     doseValue.massPerWeight.hasOwnProperty( 'max' ) ) { | |||
|                      // getValueString will simplify the value and may adjust the units | |||
|                     var massPerWeightMinValue = math.unit( mw.calculators.getValueString( doseValue.massPerWeight.min ) ); | |||
|                      var massPerWeightMaxValue = math.unit( mw.calculators.getValueString( doseValue.massPerWeight.max ) ); | |||
|                      var  | |||
|                      if(  |                      if( massPerWeightMinValue.formatUnits() !== massPerWeightMaxValue.formatUnits() ) { | ||
|                          // If the units between min and max don't match, show both | |||
|                         massPerWeightHtml += mw.calculators.getValueString( massPerWeightMinValue ); | |||
|                      } else { |                      } else { | ||
|                          massPerWeightHtml += mw.calculators.getValueNumber( massPerWeightMinValue ); | |||
|                      } |                      } | ||
|                     massPerWeightHtml += dash; | |||
|                     massPerWeightHtml += mw.calculators.getValueString( massPerWeightMaxValue ); | |||
|                  } |                  } | ||
|                 if( massPerWeightHtml ) { | |||
|                     if( administration && ! administrationDisplayed ) { | |||
|                         massPerWeightHtml += ' ' + administration; | |||
|                         administrationDisplayed = true; | |||
|                     } | |||
|                     var massPerWeightNotesHtml = ''; | |||
|                     if( doseValue.mass.hasOwnProperty( 'absoluteMax' ) ) { | |||
|                         massPerWeightNotesHtml += 'Max: ' + mw.calculators.getValueString( doseValue.mass.absoluteMax ); | |||
|                     } | |||
|                     if( dose.weightCalculation && dose.weightCalculation[ 0 ].id !== 'tbw' ) { | |||
|                         if( massPerWeightNotesHtml ) { | |||
|                             massPerWeightNotesHtml += ', '; | |||
|                         } | |||
|                         massPerWeightNotesHtml += dose.weightCalculation[ 0 ].getLabelString(); | |||
|                     } | |||
|                     if( massPerWeightNotesHtml ) { | |||
|                         massPerWeightHtml += ' (' + massPerWeightNotesHtml + ')'; | |||
|                     } | |||
|                     massPerWeightHtml = $( '<li>' ).append( massPerWeightHtml ); | |||
|                     $doseList.append( massPerWeightHtml ); | |||
|                 } | |||
|                 var massHtml = ''; | |||
|                 if( doseValue.mass.hasOwnProperty( 'dose' ) ) { | |||
|                     massHtml += mw.calculators.getValueString( doseValue.mass.dose ); | |||
|                 } else if( doseValue.mass.hasOwnProperty( 'min' ) && | |||
|                     doseValue.mass.hasOwnProperty( 'max' ) ) { | |||
|                     // getValueString will simplify the value and may adjust the units | |||
|                     var massMinValue = math.unit( mw.calculators.getValueString( doseValue.mass.min ) ); | |||
|                     var massMaxValue = math.unit( mw.calculators.getValueString( doseValue.mass.max ) ); | |||
|                     if( massMinValue.formatUnits() !== massMaxValue.formatUnits() ) { | |||
|                         // If the units between min and max don't match, show both | |||
|                         massHtml += mw.calculators.getValueString( massMinValue ); | |||
|                     } else { | |||
|                         massHtml += mw.calculators.getValueNumber( massMinValue ); | |||
|                     } | |||
|                     massHtml += dash; | |||
|                      massHtml += mw.calculators.getValueString( massMaxValue ); | |||
|                 } | |||
|                  if( massHtml ) { | |||
|                      if( administration && ! administrationDisplayed ) { | |||
|                         massHtml += ' ' + administration; | |||
|                         administrationDisplayed = true; | |||
|                     } | |||
|                     if( dose.weightCalculation.length && doseValue.weightCalculation.id !== dose.weightCalculation[ 0 ].id ) { | |||
|                         var weightCalculationLabel = doseValue.weightCalculation.getLabelString(); | |||
|                         massHtml += '  (' + weightCalculationLabel + ' ' + $( '<i>', { | |||
|                             class: 'far fa-question-circle' | |||
|                         } )[ 0 ].outerHTML + ')'; | |||
|                     } | |||
|                     massHtml = $( '<li>' ).append( massHtml ); | |||
|                     $doseList.append( massHtml ); | |||
|                 } | |||
|                 var volumeHtml = ''; | |||
|                 if( doseValue.volume.hasOwnProperty( 'dose' ) ) { | |||
|                     volumeHtml += mw.calculators.getValueString( doseValue.volume.dose ); | |||
|                 } else if( doseValue.volume.hasOwnProperty( 'min' ) && | |||
|                     doseValue.volume.hasOwnProperty( 'max' ) ) { | |||
|                     // getValueString will simplify the value and may adjust the units | |||
|                     var volumeMinValue = math.unit( mw.calculators.getValueString( doseValue.volume.min ) ); | |||
|                     var volumeMaxValue = math.unit( mw.calculators.getValueString( doseValue.volume.max ) ); | |||
|                     if( volumeMinValue.formatUnits() !== volumeMaxValue.formatUnits() ) { | |||
|                         // If the units between min and max don't match, show both | |||
|                         volumeHtml += mw.calculators.getValueString( volumeMinValue ); | |||
|                     } else { | |||
|                         volumeHtml += mw.calculators.getValueNumber( volumeMinValue ); | |||
|                     } | |||
|                     volumeHtml += dash; | |||
|                     volumeHtml += mw.calculators.getValueString( doseValue.volume.max ); | |||
|                 } | |||
|                 if( volumeHtml ) { | |||
|                     if( administration && ! administrationDisplayed ) { | |||
|                         volumeHtml += ' ' + administration; | |||
|                         administrationDisplayed = true; | |||
|                     } | |||
|                     volumeHtml = $( '<li>' ).append( volumeHtml ); | |||
|                     $doseList.append( volumeHtml ); | |||
|                     hasVolume = true; | |||
|                 } | |||
|                  $doseData.append( $doseList ); | |||
|              } |              } | ||
|              $dose.append( $doseData ); | |||
|          } |          } | ||
|         // Options column | |||
|         var $options = $( '<div>', { | |||
|             class: 'col-4 calculator-DrugDosageCalculator-options-cell' | |||
|         } ); | |||
|          var indications = this.drug.getIndications(); | |||
|         if( indications.length ) { | |||
|             $options.append( mw.calculators.getVariable( this.getVariableIds().indication ).createInput({ | |||
|                 class: 'calculator-container-input-DrugDosageCalculator-options', | |||
|                 hideLabelMobile: true, | |||
|                 inline: true | |||
|             } ) ); | |||
|         } | |||
|          var routes = this.drug.getRoutes(); | |||
|          if( routes.length ) { | |||
|          if(  |              $options.append( mw.calculators.getVariable( this.getVariableIds().route  ).createInput({ | ||
|                 class: 'calculator-container-input-DrugDosageCalculator-options', | |||
|                 hideLabelMobile: true, | |||
|                 inline: true | |||
|              } ) ); | |||
|          } |          } | ||
|         // Don't show preparations if there isn't a dose with volume | |||
|         if( hasVolume ) { | |||
|             var preparations = this.drug.getPreparations(); | |||
|             if( preparations.length ) { | |||
|                 $options.append( mw.calculators.getVariable( this.getVariableIds().preparation  ).createInput({ | |||
|                     class: 'calculator-container-input-DrugDosageCalculator-options', | |||
|                     hideLabelMobile: true, | |||
|                     inline: true | |||
|                 } ) ); | |||
|              } | |||
|          } |          } | ||
|          $calculationContainer | |||
|             .append( $( '<div>', { | |||
|                     class: 'col-12 border' | |||
|                 } ).append( | |||
|                     $drugLabel, | |||
|                     $( '<div>', { | |||
|                         class: 'row calculator-DrugDosageCalculator-dosage-row' | |||
|                     } ) | |||
|                         .append( | |||
|                             $dose, | |||
|                             $options | |||
|                         ) | |||
|                 ) | |||
|             ); | |||
|          return; | |||
|          var calculation = this; |          var calculation = this; | ||
| Line 1,355: | Line 1,279: | ||
|              $( this ).empty(); |              $( this ).empty(); | ||
|              var $infoButton = null; |              var $infoButton = null; | ||
|              if(  |              if( this.hasInfo() ) { | ||
|                  $infoButton = $( '<a>', { |                  $infoButton = $( '<a>', { | ||
|                      'data-toggle': 'collapse', |                      'data-toggle': 'collapse', | ||
|                      href: '#' +  |                      href: '#' + this.getContainerClass() + '-info', | ||
|                      role: 'button', |                      role: 'button', | ||
|                      'aria-expanded': 'false', |                      'aria-expanded': 'false', | ||
|                      'aria-controls':  |                      'aria-controls': this.getContainerClass() + '-info' | ||
|                  } ) |                  } ) | ||
|                      .append( $( '<i>', { |                      .append( $( '<i>', { | ||
|                          class: 'far fa-question-circle' |                          class: 'far fa-question-circle' | ||
|                      } ) ); |                      } ) ); | ||
|                  $label | |||
|                      .append( $( '<span>', { | |||
|                             class: 'calculator-calculation-column-label-info' | |||
|                          } ) | |||
|                             .append( $infoButton ) | |||
|                      ); | |||
|                  $ | |||
|                      .append( $( '< | |||
|              } |              } | ||
| Line 1,435: | Line 1,344: | ||
|                  } |                  } | ||
|                  $infoContainer = $( '<tr>', { | |||
|                     id: infoContainerId, | |||
|                     class: 'collapse' | |||
|                 } ) | |||
|                     .append( $( '<td>', { | |||
|                         colspan: 2 | |||
|                     } ).append( infoHtml ) ); | |||
|                  $( this ).after( $infoContainer ); |                  $( this ).after( $infoContainer ); | ||
|              } |              } | ||
|         } ); | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugDosageCalculation.prototype.getCalculationData = function() { | |||
|         var inputData = new mw.calculators.objectClasses.CalculationData(); | |||
|         // Add variables created by this calculation | |||
|         var variableIds = this.getVariableIds(); | |||
|         for( var variableType in variableIds ) { | |||
|             inputData.variables.optional.push( variableIds[ variableType ] ); | |||
|         } | |||
|         var dataTypes = inputData.getDataTypes(); | |||
|         // Data is only actually required if it is required by every dosage for the drug. | |||
|         // Data marked as required by an individual dosage that does not appear in every | |||
|         // dosage will be converted to optional. | |||
|         var requiredInputData = new mw.calculators.objectClasses.CalculationData(); | |||
|         // Need a way to tell the first iteration of the loop to initialize the required variables to a value that | |||
|         // is distinct from the empty array (populated across loop using array intersect, so could become [] and shouldn't | |||
|         // reinitialize). | |||
|         var initializeRequiredData = true; | |||
|         // Iterate through each dosage to determine variable dependency | |||
|         for( var iDosage in this.drug.dosages ) { | |||
|             var dosageInputData = this.drug.dosages[ iDosage ].getCalculationData(); | |||
|              inputData = inputData.merge( dosageInputData ); | |||
|                  var  |             for( var iDataType in dataTypes ) { | ||
|                  var dataType = dataTypes[ iDataType ]; | |||
|                  if(  |                  if( initializeRequiredData ) { | ||
|                      requiredInputData[ dataType ].required = inputData[ dataType ].required; | |||
|                  } else { |                  } else { | ||
|                      // Data is only truly required if it is required by all dosage calculations, so use array intersection | |||
|                     requiredInputData[ dataType ].required = requiredInputData[ dataType ].required.filter( function( index ) { | |||
|                      }  |                          return dosageInputData[ dataType ].required.indexOf( index ) !== -1; | ||
|                      } ); | |||
|                  } |                  } | ||
|             } | |||
|             initializeRequiredData = false; | |||
|         } | |||
|         for( var iDataType in dataTypes ) { | |||
|              } |             var dataType = dataTypes[ iDataType ]; | ||
|          }  | |||
|             // Move any data marked required in inputData to optional if it not actually required (i.e. doesn't appear | |||
|             // in requiredInputData). | |||
|             inputData[ dataType ].optional = inputData[ dataType ].optional.concat( inputData[ dataType ].required.filter( function( index ) { | |||
|                  return requiredInputData[ dataType ].required.indexOf( index ) === -1; | |||
|              } ) ).filter( mw.calculators.uniqueValues ); | |||
|             inputData[ dataType ].required = requiredInputData[ dataType ].required; | |||
|          } | |||
|         return inputData; | |||
|      }; |      }; | ||
|     mw.calculators.objectClasses.DrugDosageCalculation.prototype.getCalculationDataValues = function() { | |||
|         var data = mw.calculators.objectClasses.AbstractCalculation.prototype.getCalculationDataValues.call( this ); | |||
|         data.drug = this.drug; | |||
|         data.indication = data[ this.getVariablePrefix() + 'indication' ] !== null ? | |||
|             mw.calculators.getDrugIndication( mw.calculators.getVariable( this.getVariableIds().indication ).getValue() ) : | |||
|             null; | |||
|         delete data[ this.getVariablePrefix() + 'indication' ]; | |||
|         data.preparation = data[ this.getVariablePrefix() + 'preparation' ] !== null ? | |||
|             this.drug.preparations[ mw.calculators.getVariable( this.getVariableIds().preparation ).getValue() ] : | |||
|             null; | |||
|         delete data[ this.getVariablePrefix() + 'preparation' ]; | |||
|         data.route = data[ this.getVariablePrefix() + 'route' ] !== null ? | |||
|             mw.calculators.getDrugRoute( mw.calculators.getVariable( this.getVariableIds().route ).getValue() ) : | |||
|             null; | |||
|         delete data[ this.getVariablePrefix() + 'route' ]; | |||
|         return data; | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosageCalculation.prototype.getLabelHtml = function() { | ||
|          var $label = $( '<a>', { | |||
|             class: 'calculator-DrugDosageCalculator-drug-name', | |||
|             href: mw.util.getUrl( this.drug.name ), | |||
|             text: this.drug.name | |||
|         } ).css( 'background-color', '#fff' ); | |||
|         var highlightColor = this.drug.color.getHighlightColor(); | |||
|         if( highlightColor ) { | |||
|             var highlightContainerAttributes = { | |||
|                 class: 'calculator-DrugDosageCalculator-drug-highlight' | |||
|             }; | |||
|             var highlightContainerCss = {}; | |||
|             highlightContainerCss[ 'background' ] = highlightColor; | |||
|             $label = $( '<span>', highlightContainerAttributes ).append( $label ).css( highlightContainerCss ); | |||
|         } | |||
|         var primaryColor = this.drug.color.getPrimaryColor(); | |||
|         if( primaryColor ) { | |||
|             var backgroundContainerAttributes = { | |||
|                 class: 'calculator-DrugDosageCalculator-drug-background' | |||
|             }; | |||
|             var backgroundContainerCss = {}; | |||
|             if( this.drug.color.isStriped() ) { | |||
|                 backgroundContainerCss[ 'background' ] = 'repeating-linear-gradient(135deg,rgba(0,0,0,0),rgba(0,0,0,0)10px,rgba(255,255,255,1)10px,rgba(255,255,255,1)20px),' + primaryColor; | |||
|             } else { | |||
|                 backgroundContainerCss[ 'background'] = primaryColor; | |||
|             } | |||
|             $label = $( '<span>', backgroundContainerAttributes ).append( $label ).css( backgroundContainerCss ); | |||
|         } | |||
|         return $label; | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosageCalculation.prototype.getProperties = function() { | ||
|          return  |         var inheritedProperties = mw.calculators.objectClasses.AbstractCalculation.prototype.getProperties(); | ||
|          return this.mergeProperties( inheritedProperties, { | |||
|             required: [ | |||
|                 'drug' | |||
|             ], | |||
|             optional: [] | |||
|         } ); | |||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosageCalculation.prototype.getVariableIds = function() { | ||
|          return { |          return { | ||
|              indication: this.getVariablePrefix() + 'indication', | |||
|             preparation: this.getVariablePrefix() + 'preparation', | |||
|              route: this.getVariablePrefix() + 'route' | |||
|          }; |          }; | ||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosageCalculation.prototype.getVariableOptions = function( variableId ) { | ||
|          if(  |          if( variableId === this.getVariablePrefix() + 'indication' ) { | ||
|              this. |             return this.drug.getIndications(); | ||
|         } else if( variableId === this.getVariablePrefix() + 'preparation' ) { | |||
|             // Exclude preparations which require dilution | |||
|             return this.drug.getPreparations( true ); | |||
|         } else if( variableId === this.getVariablePrefix() + 'route' ) { | |||
|              return this.drug.getRoutes(); | |||
|          } |          } | ||
|     }; | |||
|     mw.calculators.objectClasses.DrugDosageCalculation.prototype.getVariablePrefix = function() { | |||
|         return this.drug.id + '-'; | |||
|     }; | |||
|     mw.calculators.objectClasses.DrugDosageCalculation.prototype.initialize = function() { | |||
|         if( typeof this.drug === 'string' ) { | |||
|             var drug = mw.calculators.getDrug( this.drug ); | |||
|             if( !drug ) { | |||
|                 throw new Error( 'DrugDosage references drug "' + this.drug + '" which is not defined' ); | |||
|             } | |||
|             this.drug = drug; | |||
|          } |          } | ||
|         this.updateVariables(); | |||
|         mw.calculators.objectClasses.AbstractCalculation.prototype.initialize.call( this ); | |||
|      }; |      }; | ||
|     mw.calculators.objectClasses.DrugDosageCalculation.prototype.updateVariables = function() { | |||
|         var variableIds = this.getVariableIds(); | |||
|         for( var variableType in variableIds ) { | |||
|             var variableId = variableIds[ variableType ]; | |||
|             var variableOptions = this.getVariableOptions( variableId ); | |||
|             var variableOptionValues = {}; | |||
|             var defaultOption = 0; | |||
|             for( var iVariableOption in variableOptions ) { | |||
|                 var variableOption = variableOptions[ iVariableOption ]; | |||
|                 defaultOption = variableOption.default ? iVariableOption : defaultOption; | |||
|                 variableOptionValues[ variableOption.id ] = String( variableOption ); | |||
|             } | |||
|             var defaultValue = variableOptions.length ? variableOptions[ defaultOption ].id : null; | |||
|             var variable = mw.calculators.getVariable( variableId ); | |||
|             if( !variable ) { | |||
|                 var newVariable = {}; | |||
|                 newVariable[ variableId ] = { | |||
|                     name: variableType.charAt(0).toUpperCase() + variableType.slice(1), | |||
|                     type: 'string', | |||
|                     defaultValue: defaultValue, | |||
|                     options: variableOptionValues | |||
|                 }; | |||
|                 mw.calculators.addVariables( newVariable ); | |||
|             } else { | |||
|                 // Probably not ideal to reach into the variable to change these things directly | |||
|                 // Perhaps add helper functions to variable class | |||
|                 mw.calculators.variables[ variableId ].defaultValue = defaultValue; | |||
|                 mw.calculators.variables[ variableId ].options = variableOptionValues; | |||
|             } | |||
|         } | |||
|     }; | |||
|     mw.calculators.addDrugCalculators = function( moduleId, drugCalculatorData, className ) { | |||
|         className = className ? className : 'DrugDosageCalculator'; | |||
|         for( var drugCalculatorId in drugCalculatorData ) { | |||
|             drugCalculatorData[ drugCalculatorId ].module = moduleId; | |||
|             for( var iCalculation in drugCalculatorData[ drugCalculatorId].calculations ) { | |||
|                 drugCalculatorData[ drugCalculatorId].calculations[ iCalculation ] = moduleId + '-' + | |||
|                     drugCalculatorData[ drugCalculatorId].calculations[ iCalculation ]; | |||
|             } | |||
|         } | |||
|         mw.calculators.addCalculators( moduleId, drugCalculatorData, className ); | |||
|     }; | |||
|      /** |      /** | ||
|       * Class  |       * Class DrugDosageCalculator | ||
|       * @param {Object} propertyValues |       * @param {Object} propertyValues | ||
|       * @returns {mw.calculators.objectClasses. |       * @returns {mw.calculators.objectClasses.DrugDosageCalculator} | ||
|       * @constructor |       * @constructor | ||
|       */ |       */ | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosageCalculator = function( propertyValues ) { | ||
|          mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues ); |          mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues ); | ||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosageCalculator.prototype = Object.create( mw.calculators.objectClasses.AbstractCalculator.prototype ); | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosageCalculator.prototype.doRender = function() { | ||
|          var $calculatorContainer = $( '.' + this.getContainerClass() ); |          var $calculatorContainer = $( '.' + this.getContainerClass() ); | ||
| Line 1,554: | Line 1,619: | ||
|          $calculatorContainer.addClass( this.getCalculatorClass() ); |          $calculatorContainer.addClass( this.getCalculatorClass() ); | ||
|          $calculatorContainer.empty(); |          $calculatorContainer.empty(); | ||
| Line 1,565: | Line 1,626: | ||
|          } ) ); |          } ) ); | ||
|          var  |          var $calculationsContainer = $( '<div>', { | ||
|              class: 'container-fluid' | |||
|          } ); | |||
|          }  | |||
|          $calculatorContainer.append( $calculationsContainer ); |          $calculatorContainer.append( $calculationsContainer ); | ||
| Line 1,591: | Line 1,634: | ||
|          for( var iCalculationId in this.calculations ) { |          for( var iCalculationId in this.calculations ) { | ||
|              var calculation = mw.calculators.getCalculation( this.calculations[ iCalculationId ] ); |              var calculation = mw.calculators.getCalculation( this.calculations[ iCalculationId ] ); | ||
|              var calculationContainerClass = calculation.getContainerClass(); |              var calculationContainerClass = 'row no-gutters ' + calculation.getContainerClass(); | ||
|              var $calculationContainer = $( ' |              var $calculationContainer = $( '<div>', { | ||
|                 class: calculationContainerClass | |||
|             } ); | |||
|              $calculationsContainer.append( $calculationContainer ); | |||
|              calculation.render(); |              calculation.render(); | ||
| Line 1,614: | Line 1,646: | ||
|      }; |      }; | ||
|      mw.calculators.objectClasses. |      mw.calculators.objectClasses.DrugDosageCalculator.prototype.getCalculatorClass = function() { | ||
|          return 'calculator- |          return 'calculator-DrugDosageCalculator'; | ||
|      }; |      }; | ||
|      mw.calculators.objectClasses.DrugDosageCalculator.prototype.getProperties = function() { | |||
|      mw.calculators.objectClasses. | |||
|          var inheritedProperties = mw.calculators.objectClasses.AbstractCalculator.prototype.getProperties(); |          var inheritedProperties = mw.calculators.objectClasses.AbstractCalculator.prototype.getProperties(); | ||
|          return this.mergeProperties( inheritedProperties, { |          return this.mergeProperties( inheritedProperties, { | ||
|              required: [], |              required: [], | ||
|              optional: [ |              optional: [] | ||
|          } ); |          } ); | ||
|      }; |      }; | ||
| }() ); | }() ); | ||
Revision as of 23:13, 21 August 2021
/**
 * @author Chris Rishel
 */
( function() {
    var DEFAULT_DRUG_COLOR = 'default';
    var DEFAULT_DRUG_POPULATION = 'general';
    var DEFAULT_DRUG_ROUTE = 'iv';
    mw.calculators.isValueDependent = function( value, variableId ) {
        // This may need generalized to support other variables in the future
        if( variableId === 'weight' ) {
            return value && value.formatUnits().match( /\/[\s(]*?kg/ );
        } else {
            throw new Error( 'Dependence "' + variableId + '" not supported by isValueDependent' );
        }
    };
    /**
     * Define units
     */
    mw.calculators.addUnitsBases( {
        concentration: {
            toString: function( units ) {
                units = units.replace( ' pct', '%' );
                units = units.replace( 'ug', 'mcg' );
                return units;
            }
        },
        mass: {
            toString: function( units ) {
                units = units.replace( 'ug', 'mcg' );
                return units;
            }
        }
    } );
    mw.calculators.addUnits( {
        mcg: {
            baseName: 'mass',
            definition: '1 ug'
        },
        pct: {
            baseName: 'concentration',
            definition: '10 mg/mL'
        },
        vial: {
            baseName: 'volume'
        }
    } );
    /**
     * DrugColor
     */
    mw.calculators.drugColors = {};
    mw.calculators.addDrugColors = function( drugColorData ) {
        var drugColors = mw.calculators.createCalculatorObjects( 'DrugColor', drugColorData );
        for( var drugColorId in drugColors ) {
            mw.calculators.drugColors[ drugColorId ] = drugColors[ drugColorId ];
        }
    };
    mw.calculators.getDrugColor = function( drugColorId ) {
        if( mw.calculators.drugColors.hasOwnProperty( drugColorId ) ) {
            return mw.calculators.drugColors[ drugColorId ];
        } else {
            return null;
        }
    };
    /**
     * Class DrugColor
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugColor}
     * @constructor
     */
    mw.calculators.objectClasses.DrugColor = function( propertyValues ) {
        var properties = {
            required: [
                'id'
            ],
            optional: [
                'parentColor',
                'primaryColor',
                'highlightColor',
                'striped'
            ]
        };
        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );
        this.parentColor = this.parentColor || this.id === DEFAULT_DRUG_COLOR ? this.parentColor : DEFAULT_DRUG_COLOR;
    };
    mw.calculators.objectClasses.DrugColor.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );
    mw.calculators.objectClasses.DrugColor.prototype.getParentDrugColor = function() {
        if( !this.parentColor ) {
            return null;
        }
        var parentDrugColor = mw.calculators.getDrugColor( this.parentColor );
        if( !parentDrugColor ) {
            throw new Error( 'Parent drug color "' + this.parentColor + '" not found for drug color "' + this.id + '"' );
        }
        return parentDrugColor;
    };
    mw.calculators.objectClasses.DrugColor.prototype.getHighlightColor = function() {
        if( this.highlightColor ) {
            return this.highlightColor;
        } else if( this.parentColor ) {
            return this.getParentDrugColor().getHighlightColor();
        }
    };
    mw.calculators.objectClasses.DrugColor.prototype.getPrimaryColor = function() {
        if( this.primaryColor ) {
            return this.primaryColor;
        } else if( this.parentColor ) {
            return this.getParentDrugColor().getPrimaryColor();
        }
    };
    mw.calculators.objectClasses.DrugColor.prototype.isStriped = function() {
        if( this.striped !== null ) {
            return this.striped;
        } else if( this.parentColor ) {
            return this.getParentDrugColor().isStriped();
        }
    };
    /**
     * DrugPopulation
     */
    mw.calculators.drugPopulations = {};
    mw.calculators.addDrugPopulations = function( drugPopulationData ) {
        var drugPopulations = mw.calculators.createCalculatorObjects( 'DrugPopulation', drugPopulationData );
        for( var drugPopulationId in drugPopulations ) {
            mw.calculators.drugPopulations[ drugPopulationId ] = drugPopulations[ drugPopulationId ];
        }
    };
    mw.calculators.getDrugPopulation = function( drugPopulationId ) {
        if( mw.calculators.drugPopulations.hasOwnProperty( drugPopulationId ) ) {
            return mw.calculators.drugPopulations[ drugPopulationId ];
        } else {
            return null;
        }
    };
    /**
     * Class DrugPopulation
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugPopulation}
     * @constructor
     */
    mw.calculators.objectClasses.DrugPopulation = function( propertyValues ) {
        var properties = {
            required: [
                'id',
                'name'
            ],
            optional: [
                'abbreviation',
                'variables'
            ]
        };
        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );
        if( this.variables ) {
            for( var variableId in this.variables ) {
                if( !mw.calculators.getVariable( variableId ) ) {
                    throw new Error( 'DrugPopulation variable "' + variableId + '" not defined' );
                }
                this.variables[ variableId ].min = this.variables[ variableId ].hasOwnProperty( 'min' ) ?
                    math.unit( this.variables[ variableId ].min ) : null;
                this.variables[ variableId ].max = this.variables[ variableId ].hasOwnProperty( 'max' ) ?
                    math.unit( this.variables[ variableId ].max ) : null;
            }
        } else {
            this.variables = {};
        }
    };
    mw.calculators.objectClasses.DrugPopulation.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );
    mw.calculators.objectClasses.DrugPopulation.prototype.getCalculationData = function() {
        var inputData = new mw.calculators.objectClasses.CalculationData();
        for( var variableId in this.variables ) {
            inputData.variables.required.push( variableId );
        }
        return inputData;
    };
    mw.calculators.objectClasses.DrugPopulation.prototype.getCalculationDataScore = function( dataValues ) {
        // A return value of -1 indicates the data did not match the population definition
        for( var variableId in this.variables ) {
            if( !dataValues.hasOwnProperty( variableId ) ) {
                return -1;
            }
            if( this.variables[ variableId ].min &&
                ( !dataValues[ variableId ] ||
                    !math.largerEq( dataValues[ variableId ], this.variables[ variableId ].min ) ) ) {
                return -1;
            }
            if( this.variables[ variableId ].max &&
                ( !dataValues[ variableId ] ||
                    !math.smallerEq( dataValues[ variableId ], this.variables[ variableId ].max ) ) ) {
                return -1;
            }
        }
        // If the data matches the population definition, the score corresponds to the number of variables in the
        // population definition. This should roughly correspond to the specificity of the population.
        return Object.keys( this.variables ).length;
    };
    mw.calculators.objectClasses.DrugPopulation.prototype.toString = function() {
        return mw.calculators.isMobile() && this.abbreviation ? this.abbreviation : this.name;
    };
    /**
     * DrugRoute
     */
    mw.calculators.drugRoutes = {};
    mw.calculators.addDrugRoutes = function( drugRouteData ) {
        var drugRoutes = mw.calculators.createCalculatorObjects( 'DrugRoute', drugRouteData );
        for( var drugRouteId in drugRoutes ) {
            mw.calculators.drugRoutes[ drugRouteId ] = drugRoutes[ drugRouteId ];
        }
    };
    mw.calculators.getDrugRoute = function( drugRouteId ) {
        if( mw.calculators.drugRoutes.hasOwnProperty( drugRouteId ) ) {
            return mw.calculators.drugRoutes[ drugRouteId ];
        } else {
            return null;
        }
    };
    /**
     * Class DrugRoute
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugRoute}
     * @constructor
     */
    mw.calculators.objectClasses.DrugRoute = function( propertyValues ) {
        var properties = {
            required: [
                'id',
                'name'
            ],
            optional: [
                'abbreviation',
                'default'
            ]
        };
        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );
    };
    mw.calculators.objectClasses.DrugRoute.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );
    mw.calculators.objectClasses.DrugRoute.prototype.toString = function() {
        return mw.calculators.isMobile() && this.abbreviation ? this.abbreviation : this.name;
    };
    /**
     * DrugIndication
     */
    mw.calculators.drugIndications = {};
    mw.calculators.addDrugIndications = function( drugIndicationData ) {
        var drugIndications = mw.calculators.createCalculatorObjects( 'DrugIndication', drugIndicationData );
        for( var drugIndicationId in drugIndications ) {
            mw.calculators.drugIndications[ drugIndicationId ] = drugIndications[ drugIndicationId ];
        }
    };
    mw.calculators.getDrugIndication = function( drugIndicationId ) {
        if( mw.calculators.drugIndications.hasOwnProperty( drugIndicationId ) ) {
            return mw.calculators.drugIndications[ drugIndicationId ];
        } else {
            return null;
        }
    };
    /**
     * Class DrugIndication
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugIndication}
     * @constructor
     */
    mw.calculators.objectClasses.DrugIndication = function( propertyValues ) {
        var properties = {
            required: [
                'id',
                'name'
            ],
            optional: [
                'abbreviation',
                'default'
            ]
        };
        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );
    };
    mw.calculators.objectClasses.DrugIndication.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );
    mw.calculators.objectClasses.DrugIndication.prototype.toString = function() {
        return mw.calculators.isMobile() && this.abbreviation ? this.abbreviation : this.name;
    };
    /**
     * Drug
     */
    mw.calculators.drugs = {};
    mw.calculators.addDrugs = function( drugData ) {
        var drugs = mw.calculators.createCalculatorObjects( 'Drug', drugData );
        for( var drugId in drugs ) {
            mw.calculators.drugs[ drugId ] = drugs[ drugId ];
            var drugDosageCalculationId = mw.calculators.getDrugDosageCalculationId( drugId );
            var drugDosageCalculation = mw.calculators.getCalculation( drugDosageCalculationId );
            if( !drugDosageCalculation ) {
                var calculationData = {};
                calculationData[ drugDosageCalculationId ] = {
                    calculate: mw.calculators.objectClasses.DrugDosageCalculation.prototype.calculate,
                    drug: drugId,
                    type: 'drug'
                };
                mw.calculators.addCalculations( calculationData, 'DrugDosageCalculation' );
                drugDosageCalculation = mw.calculators.getCalculation( drugDosageCalculationId );
            }
            drugDosageCalculation.setDependencies();
        }
    };
    mw.calculators.addDrugDosages = function( drugId, drugDosageData ) {
        var drug = mw.calculators.getDrug( drugId );
        if( !drug ) {
            throw new Error( 'DrugDosage references drug "' + drugId + '" which is not defined' );
        }
        drug.addDosages( drugDosageData );
        // Update calculation dependencies
        var drugDosageCalculation = mw.calculators.getCalculation( mw.calculators.getDrugDosageCalculationId( drugId ) );
        drugDosageCalculation.updateVariables();
        drugDosageCalculation.setDependencies();
    };
    mw.calculators.getDrug = function( drugId ) {
        if( mw.calculators.drugs.hasOwnProperty( drugId ) ) {
            return mw.calculators.drugs[ drugId ];
        } else {
            return null;
        }
    };
    /**
     * Class Drug
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.Drug}
     * @constructor
     */
    mw.calculators.objectClasses.Drug = function( propertyValues ) {
        mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues );
        if( !this.color ) {
            this.color = DEFAULT_DRUG_COLOR;
        }
        var color = mw.calculators.getDrugColor( this.color );
        if( !color ) {
            throw new Error( 'Invalid drug color "' + this.color + '" for drug "' + this.id + '"' );
        }
        this.color = color;
        if( this.preparations ) {
            var preparationData = this.preparations;
            this.preparations = [];
            this.addPreparations( preparationData );
        } else {
            this.preparations = [];
        }
        if( this.dosages ) {
            var dosageData = this.dosages;
            this.dosages = [];
            this.addDosages( dosageData );
        } else {
            this.dosages = [];
        }
    };
    mw.calculators.objectClasses.Drug.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );
    mw.calculators.objectClasses.Drug.prototype.addDosages = function( dosageData ) {
        var dosages = mw.calculators.createCalculatorObjects( 'DrugDosage', dosageData );
        for( var dosageId in dosages ) {
            dosages[ dosageId ].id = this.dosages.length;
            this.dosages.push( dosages[ dosageId ] );
        }
    };
    mw.calculators.objectClasses.Drug.prototype.addPreparations = function( preparationData ) {
        var preparations = mw.calculators.createCalculatorObjects( 'DrugPreparation', preparationData );
        for( var preparationId in preparations ) {
            preparations[ preparationId ].id = this.preparations.length;
            this.preparations.push( preparations[ preparationId ] );
        }
    };
    mw.calculators.objectClasses.Drug.prototype.getIndications = function() {
        var indications = [];
        for( var iDosage in this.dosages ) {
            if( this.dosages[ iDosage ].indication ) {
                indications.push( this.dosages[ iDosage ].indication );
            }
        }
        return indications.filter( mw.calculators.uniqueValues );
    };
    mw.calculators.objectClasses.Drug.prototype.getPopulations = function( indicationId ) {
        var populations = [];
        for( var iDosage in this.dosages ) {
            if( this.dosages[ iDosage ].population &&
                ( !indicationId || ( this.dosages[ iDosage ].indication && this.dosages[ iDosage ].indication.id === indicationId ) ) ) {
                populations.push( this.dosages[ iDosage ].population );
            }
        }
        return populations.filter( mw.calculators.uniqueValues );
    };
    mw.calculators.objectClasses.Drug.prototype.getRoutes = function( indicationId ) {
        var routes = [];
        for( var iDosage in this.dosages ) {
            if( this.dosages[ iDosage ].route &&
                ( !indicationId || ( this.dosages[ iDosage ].indication && this.dosages[ iDosage ].indication.id === indicationId ) ) ) {
                routes.push( this.dosages[ iDosage ].route );
            }
        }
        return routes.filter( mw.calculators.uniqueValues );
    };
    mw.calculators.objectClasses.Drug.prototype.getPreparations = function( excludeDilutionRequired ) {
        var preparations = this.preparations.filter( mw.calculators.uniqueValues );
        if( excludeDilutionRequired ) {
            for( var iPreparation in preparations ) {
                if( preparations[ iPreparation ].dilutionRequired ) {
                    delete preparations[ iPreparation ];
                }
            }
        }
        return preparations;
    };
    mw.calculators.objectClasses.Drug.prototype.getProperties = function() {
        return {
            required: [
                'id',
                'name'
            ],
            optional: [
                'color',
                'dosages',
                'preparations'
            ]
        };
    };
    /**
     * DrugPreparation
     */
    mw.calculators.addDrugPreparations = function( drugId, drugPreparationData ) {
        var drug = mw.calculators.getDrug( drugId );
        if( !drug ) {
            throw new Error( 'DrugPreparation references drug "' + drugId + '" which is not defined' );
        }
        drug.addPreparations( drugPreparationData );
        var drugDosageCalculation = mw.calculators.getCalculation( mw.calculators.getDrugDosageCalculationId( drugId ) );
        drugDosageCalculation.recalculate();
    };
    /**
     * Class DrugPreparation
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugPreparation}
     * @constructor
     */
    mw.calculators.objectClasses.DrugPreparation = function( propertyValues ) {
        var properties = {
            required: [
                'id',
                'concentration'
            ],
            optional: [
                'default',
                'dilutionRequired',
                'commonDilution'
            ]
        };
        mw.calculators.objectClasses.CalculatorObject.call( this, properties, propertyValues );
        this.concentration = this.concentration.replace( 'mcg', 'ug' );
        this.concentration = math.unit( this.concentration );
    };
    mw.calculators.objectClasses.DrugPreparation.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );
    mw.calculators.objectClasses.DrugPreparation.prototype.getVolumeUnits = function() {
        // The units of concentration will always be of the form "mass / volume"
        // The regular expression matches all text leading up to the volume units
        return mw.calculators.getUnitsByBase( this.concentration ).volume;
    };
    mw.calculators.objectClasses.DrugPreparation.prototype.toString = function() {
        return mw.calculators.getValueString( this.concentration );
    };
    /**
     * Class DrugDosage
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugDosage}
     * @constructor
     */
    mw.calculators.objectClasses.DrugDosage = function( propertyValues ) {
        mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues );
        var drugIndication = mw.calculators.getDrugIndication( this.indication );
        if( !drugIndication ) {
            throw new Error( 'Invalid indication "' + this.indication + '" for drug dosage' );
        }
        this.indication = drugIndication;
        this.population = this.population ? this.population : DEFAULT_DRUG_POPULATION;
        var drugPopulation = mw.calculators.getDrugPopulation( this.population );
        if( !drugPopulation ) {
            throw new Error( 'Invalid population "' + this.population + '" for drug dosage' );
        }
        this.population = drugPopulation;
        this.route = this.route ? this.route : DEFAULT_DRUG_ROUTE;
        var drugRoute = mw.calculators.getDrugRoute( this.route );
        if( !drugRoute ) {
            throw new Error( 'Invalid route "' + this.route + '" for drug dosage' );
        }
        this.route = drugRoute;
        // Add the dose objects to the drug
        var drugDoseData = this.dose;
        this.dose = [];
        this.addDoses( drugDoseData );
    };
    mw.calculators.objectClasses.DrugDosage.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );
    mw.calculators.objectClasses.DrugDosage.prototype.addDoses = function( drugDoseData ) {
        // Each dosage can have one or more associated doses. Ensure this value is an array.
        if( !Array.isArray( drugDoseData ) ) {
            drugDoseData = [ drugDoseData ];
        }
        var doses = mw.calculators.createCalculatorObjects( 'DrugDose', drugDoseData );
        for( var doseId in doses ) {
            doses[ doseId ].id = this.dose.length;
            this.dose.push( doses[ doseId ] );
        }
    };
    mw.calculators.objectClasses.DrugDosage.prototype.getCalculationData = function() {
        var inputData = new mw.calculators.objectClasses.CalculationData();
        inputData = inputData.merge( this.population.getCalculationData() );
        for( var iDose in this.dose ) {
            inputData = inputData.merge( this.dose[ iDose ].getCalculationData() );
        }
        return inputData;
    };
    mw.calculators.objectClasses.DrugDosage.prototype.getProperties = function() {
        return {
            required: [
                'dose',
                'id',
                'indication'
            ],
            optional: [
                'description',
                'population',
                'route'
            ]
        };
    };
    mw.calculators.objectClasses.DrugDosage.prototype.hasInfo = function() {
        return this.description;
    };
    /**
     * Class DrugDose
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugDose}
     * @constructor
     */
    mw.calculators.objectClasses.DrugDose = function( propertyValues ) {
        mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues );
        if( this.weightCalculation ) {
            var weightCalculationIds = this.weightCalculation;
            // weightCalculation property will contain references to the actual objects, so reinitialize
            this.weightCalculation = [];
            if( !Array.isArray( weightCalculationIds ) ) {
                weightCalculationIds = [ weightCalculationIds ];
            }
            for( var iWeightCalculation in weightCalculationIds ) {
                var weightCalculationId = weightCalculationIds[ iWeightCalculation ];
                var weightCalculation = mw.calculators.getCalculation( weightCalculationId );
                if( !weightCalculation ) {
                    throw new Error( 'Drug dose references weight calculation "' + weightCalculationId + '" which is not defined' );
                }
                this.weightCalculation.push( weightCalculation );
            }
        } else {
            this.weightCalculation = [];
        }
        var mathProperties = this.getMathProperties();
        var isWeightDependent = false;
        for( var iMathProperty in mathProperties ) {
            var mathProperty = mathProperties[ iMathProperty ];
            if( this[ mathProperty ] ) {
                // TODO consider making a UnitsBase.weight.fromString()
                this[ mathProperty ] = this[ mathProperty ].replace( 'kg', 'kgwt' );
                this[ mathProperty ] = this[ mathProperty ].replace( 'mcg', 'ug' );
                this[ mathProperty ] = math.unit( this[ mathProperty ] );
                if( mw.calculators.isValueDependent( this[ mathProperty ], 'weight' ) ) {
                    isWeightDependent = true;
                }
            } else {
                this[ mathProperty ] = null;
            }
        }
        if( isWeightDependent ) {
            // Default is tbw
            this.weightCalculation.push( mw.calculators.getCalculation( 'tbw' ) );
        }
    };
    mw.calculators.objectClasses.DrugDose.prototype = Object.create( mw.calculators.objectClasses.CalculatorObject.prototype );
    mw.calculators.objectClasses.DrugDose.prototype.getAdministration = function() {
        var administration = '';
        if( this.frequency ) {
            administration += administration ? ' ' : '';
            administration += this.frequency;
        }
        if( this.duration ) {
            administration += administration ? ' ' : '';
            administration += 'over ' + this.duration;
        }
        return administration;
    };
    mw.calculators.objectClasses.DrugDose.prototype.getCalculationData = function() {
        var calculationData = new mw.calculators.objectClasses.CalculationData();
        for( var iWeightCalculation in this.weightCalculation ) {
            calculationData.calculations.optional.push( this.weightCalculation[ iWeightCalculation ].id );
        }
        return calculationData;
    };
    mw.calculators.objectClasses.DrugDose.prototype.getMathProperties = function() {
        return [
            'dose',
            'min',
            'max',
            'absoluteMax'
        ];
    };
    mw.calculators.objectClasses.DrugDose.prototype.getProperties = function() {
        return {
            required: [
                'id'
            ],
            optional: [
                'absoluteMax',
                'dose',
                'duration',
                'frequency',
                'min',
                'max',
                'name',
                'weightCalculation'
            ]
        };
    };
    mw.calculators.getDrugDosageCalculationId = function( drugId ) {
        return 'drugDosages-' + drugId;
    };
    /**
     * Class DrugDosageCalculation
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugDosageCalculation}
     * @constructor
     */
    mw.calculators.objectClasses.DrugDosageCalculation = function( propertyValues ) {
        mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues );
        this.initialize();
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype = Object.create( mw.calculators.objectClasses.AbstractCalculation.prototype );
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.calculate = function( data ) {
        var value = {
            dosageId: null,
            message: null,
            population: null,
            preparation: data.preparation,
            dose: []
        };
        if( !data.drug.dosages.length ) {
            value.message = 'No dose data';
            return value;
        }
        // Determine which dosage to use
        var populationScores = [];
        for( var iDosage in data.drug.dosages ) {
            var drugDosage = data.drug.dosages[ iDosage ];
            // If the indication and route do not match, set the score to -1
            var populationScore =
                drugDosage.indication.id === data.indication.id && drugDosage.route.id === data.route.id ?
                drugDosage.population.getCalculationDataScore( data ) : -1;
            populationScores.push( populationScore );
        }
        var maxPopulationScore = Math.max.apply( null, populationScores );
        if( maxPopulationScore < 0 ) {
            value.message = 'No dose data for indication "' + String( data.indication ) + '" and route "' + String( data.route ) + '"';
            return value;
        }
        // If there is more than one dosage with the same score, take the first.
        // This allows the data editor to decide which is most important.
        value.dosageId = populationScores.indexOf( maxPopulationScore );
        var dosage = data.drug.dosages[ value.dosageId ];
        // A dosage may contain multiple doses (e.g. induction and maintenance)
        for( var iDose in dosage.dose ) {
            var dose = dosage.dose[ iDose ];
            var mathProperties = dose.getMathProperties();
            var weightCalculation = null;
            var weightValue = null;
            // data.weightCalculation should be in order of preference, so take the first non-null value
            for( var iWeightCalculation in dose.weightCalculation ) {
                if( dose.weightCalculation[ iWeightCalculation ].value !== null ) {
                    weightCalculation = dose.weightCalculation[ iWeightCalculation ];
                    weightValue = dose.weightCalculation[ iWeightCalculation ].value;
                    break;
                }
            }
            // Initialize value properties for dose
            value.dose[ iDose ] = {
                massPerWeight: {},
                mass: {},
                volume: {},
                weightCalculation: weightCalculation ? weightCalculation : null
            };
            var massUnits;
            var volumeUnits;
            for( var iMathProperty in mathProperties ) {
                var mathProperty = mathProperties[ iMathProperty ];
                var doseValue = dose[ mathProperty ];
                if( doseValue ) {
                    var doseUnitsByBase = mw.calculators.getUnitsByBase( doseValue );
                    if( doseUnitsByBase.hasOwnProperty( 'weight' ) ) {
                        value.dose[ iDose ].massPerWeight[ mathProperty ] = doseValue;
                        if( weightValue ) {
                            massUnits = doseUnitsByBase.mass;
                            if( doseUnitsByBase.hasOwnProperty( 'time' ) ) {
                                massUnits += '/' + doseUnitsByBase.time;
                            }
                            // For whatever reason math.format will simplify the units, but math.formatUnits will not
                            // as a hack, we recreate a new unit value with the correct formatting of the result
                            value.dose[ iDose ].mass[ mathProperty ] = math.unit( math.multiply( doseValue, weightValue ).format() ).to( massUnits );
                        }
                    } else {
                        value.dose[ iDose ].mass[ mathProperty ] = doseValue;
                    }
                    if( data.preparation && value.dose[ iDose ].mass[ mathProperty ] ) {
                        // Same hack as above to get units to simplify correctly
                        var preparationUnitsByBase = mw.calculators.getUnitsByBase( data.preparation.concentration );
                        volumeUnits = preparationUnitsByBase.volume;
                        if( doseUnitsByBase.hasOwnProperty( 'time' ) ) {
                            volumeUnits += '/' + doseUnitsByBase.time;
                        }
                        value.dose[ iDose ].volume[ mathProperty ] = math.unit( math.multiply( value.dose[ iDose ].mass[ mathProperty ], math.divide( 1, data.preparation.concentration ) ).format() ).to( volumeUnits );
                    }
                }
            }
            if( value.dose[ iDose ].mass.hasOwnProperty( 'absoluteMax' ) ) {
                if( value.dose[ iDose ].mass.hasOwnProperty( 'min' ) && math.smaller( value.dose[ iDose ].mass.absoluteMax, value.dose[ iDose ].mass.min ) ) {
                    // Both min and max are larger than the absolute max dose, so just convert to single dose.
                    value.dose[ iDose ].mass.dose = value.dose[ iDose ].mass.absoluteMax;
                    delete value.dose[ iDose ].mass.min;
                    delete value.dose[ iDose ].mass.max;
                    if( value.dose[ iDose ].volume.hasOwnProperty( 'absoluteMax' ) ) {
                        value.dose[ iDose ].volume.dose = value.dose[ iDose ].volume.absoluteMax;
                        delete value.dose[ iDose ].volume.min;
                        delete value.dose[ iDose ].volume.max;
                    }
                } else if( value.dose[ iDose ].mass.hasOwnProperty( 'max' ) && math.smaller( value.dose[ iDose ].mass.absoluteMax, value.dose[ iDose ].mass.max ) ) {
                    value.dose[ iDose ].mass.max = value.dose[ iDose ].mass.absoluteMax;
                    if( value.dose[ iDose ].volume.hasOwnProperty( 'absoluteMax' ) ) {
                        value.dose[ iDose ].volume.max = value.dose[ iDose ].volume.absoluteMax;
                    }
                } else if( value.dose[ iDose ].mass.hasOwnProperty( 'dose' ) && math.smaller( value.dose[ iDose ].mass.absoluteMax, value.dose[ iDose ].mass.dose ) ) {
                    value.dose[ iDose ].mass.dose = value.dose[ iDose ].mass.absoluteMax;
                    if( value.dose[ iDose ].volume.hasOwnProperty( 'absoluteMax' ) ) {
                        value.dose[ iDose ].volume.dose = value.dose[ iDose ].volume.absoluteMax;
                    }
                }
            }
        }
        return value;
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.doRender = function() {
        var $calculationContainer = $( '.' + this.getContainerClass() );
        if( !$calculationContainer.length ) {
            return;
        }
        $calculationContainer.empty();
        // Drug label
        var drugLabelAttributes = {
            class: 'calculator-DrugDosageCalculator-drug-cell'
        };
        var $drugLabel = $( '<div>', drugLabelAttributes );
        $drugLabel.append( this.getLabelHtml() );
        // Dose column
        var $dose = $( '<div>', {
            class: 'col-8 calculator-DrugDosageCalculator-dose-cell'
        }  );
        var dash = '-';
        // The options column should only show the preparation if there is a calculated volume
        var hasVolume;
        if( !this.value || this.value.dosageId === null ) {
            if( this.value && this.value.hasOwnProperty( 'message' ) ) {
                $dose.append( $( '<i>' ).append( this.value.message ) );
            }
        } else {
            var dosage = this.drug.dosages[ this.value.dosageId ];
            var showInfo;
            var $doseInfo = $( '<div>', {
                class: 'calculator-DrugDosageCalculator-dose-info'
            } );
            if( dosage.population && dosage.population.id !== DEFAULT_DRUG_POPULATION ) {
                $doseInfo
                    .append( $( '<div>', {
                        class: 'calculator-DrugDosageCalculator-dose-info-population'
                    } ).append( String( dosage.population ) + ' dosing' ) );
                showInfo = true;
            }
            if( dosage.hasInfo() ) {
                var doseInfoText = mw.calculators.isMobile() ? 'Dosage info' : 'Dosage information';
                var $doseInfoLink = $( '<a>', {
                    'data-toggle': 'collapse',
                    href: '#' + this.getContainerClass() + '-dose-info-row',
                    role: 'button',
                    'aria-expanded': 'false',
                    'aria-controls': this.getContainerClass() + '-dose-info-row'
                } )
                    .append( doseInfoText + ' ' )
                    .append( $( '<i>', {
                        class: 'far fa-question-circle'
                    } ) );
                $doseInfo
                    .append( $( '<div>', {
                        class: 'calculator-DrugDosageCalculator-dose-info-button'
                    } ).append( $doseInfoLink ) );
                showInfo = true;
            }
            if( showInfo ) {
                $dose.append( $doseInfo );
            }
            var $doseData = $( '<div>', {
                class: 'calculator-DrugDosageCalculator-dose-data'
            } );
            // This will iterate through the calculated doses. iDose should exactly correspond to doses within dosage
            // to allow referencing other properties of the dose.
            for( var iDose in this.value.dose ) {
                var dose = dosage.dose[ iDose ];
                var doseValue = this.value.dose[ iDose ];
                if( dose.name ) {
                    $doseData.append( dose.name + '<br />' );
                }
                var $doseList = $( '<ul>' );
                var administration = dose.getAdministration();
                var administrationDisplayed = false;
                var massPerWeightHtml = '';
                if( doseValue.massPerWeight.hasOwnProperty( 'dose' ) ) {
                    massPerWeightHtml += mw.calculators.getValueString( doseValue.massPerWeight.dose );
                } else if( doseValue.massPerWeight.hasOwnProperty( 'min' ) &&
                    doseValue.massPerWeight.hasOwnProperty( 'max' ) ) {
                    // getValueString will simplify the value and may adjust the units
                    var massPerWeightMinValue = math.unit( mw.calculators.getValueString( doseValue.massPerWeight.min ) );
                    var massPerWeightMaxValue = math.unit( mw.calculators.getValueString( doseValue.massPerWeight.max ) );
                    if( massPerWeightMinValue.formatUnits() !== massPerWeightMaxValue.formatUnits() ) {
                        // If the units between min and max don't match, show both
                        massPerWeightHtml += mw.calculators.getValueString( massPerWeightMinValue );
                    } else {
                        massPerWeightHtml += mw.calculators.getValueNumber( massPerWeightMinValue );
                    }
                    massPerWeightHtml += dash;
                    massPerWeightHtml += mw.calculators.getValueString( massPerWeightMaxValue );
                }
                if( massPerWeightHtml ) {
                    if( administration && ! administrationDisplayed ) {
                        massPerWeightHtml += ' ' + administration;
                        administrationDisplayed = true;
                    }
                    var massPerWeightNotesHtml = '';
                    if( doseValue.mass.hasOwnProperty( 'absoluteMax' ) ) {
                        massPerWeightNotesHtml += 'Max: ' + mw.calculators.getValueString( doseValue.mass.absoluteMax );
                    }
                    if( dose.weightCalculation && dose.weightCalculation[ 0 ].id !== 'tbw' ) {
                        if( massPerWeightNotesHtml ) {
                            massPerWeightNotesHtml += ', ';
                        }
                        massPerWeightNotesHtml += dose.weightCalculation[ 0 ].getLabelString();
                    }
                    if( massPerWeightNotesHtml ) {
                        massPerWeightHtml += ' (' + massPerWeightNotesHtml + ')';
                    }
                    massPerWeightHtml = $( '<li>' ).append( massPerWeightHtml );
                    $doseList.append( massPerWeightHtml );
                }
                var massHtml = '';
                if( doseValue.mass.hasOwnProperty( 'dose' ) ) {
                    massHtml += mw.calculators.getValueString( doseValue.mass.dose );
                } else if( doseValue.mass.hasOwnProperty( 'min' ) &&
                    doseValue.mass.hasOwnProperty( 'max' ) ) {
                    // getValueString will simplify the value and may adjust the units
                    var massMinValue = math.unit( mw.calculators.getValueString( doseValue.mass.min ) );
                    var massMaxValue = math.unit( mw.calculators.getValueString( doseValue.mass.max ) );
                    if( massMinValue.formatUnits() !== massMaxValue.formatUnits() ) {
                        // If the units between min and max don't match, show both
                        massHtml += mw.calculators.getValueString( massMinValue );
                    } else {
                        massHtml += mw.calculators.getValueNumber( massMinValue );
                    }
                    massHtml += dash;
                    massHtml += mw.calculators.getValueString( massMaxValue );
                }
                if( massHtml ) {
                    if( administration && ! administrationDisplayed ) {
                        massHtml += ' ' + administration;
                        administrationDisplayed = true;
                    }
                    if( dose.weightCalculation.length && doseValue.weightCalculation.id !== dose.weightCalculation[ 0 ].id ) {
                        var weightCalculationLabel = doseValue.weightCalculation.getLabelString();
                        massHtml += '  (' + weightCalculationLabel + ' ' + $( '<i>', {
                            class: 'far fa-question-circle'
                        } )[ 0 ].outerHTML + ')';
                    }
                    massHtml = $( '<li>' ).append( massHtml );
                    $doseList.append( massHtml );
                }
                var volumeHtml = '';
                if( doseValue.volume.hasOwnProperty( 'dose' ) ) {
                    volumeHtml += mw.calculators.getValueString( doseValue.volume.dose );
                } else if( doseValue.volume.hasOwnProperty( 'min' ) &&
                    doseValue.volume.hasOwnProperty( 'max' ) ) {
                    // getValueString will simplify the value and may adjust the units
                    var volumeMinValue = math.unit( mw.calculators.getValueString( doseValue.volume.min ) );
                    var volumeMaxValue = math.unit( mw.calculators.getValueString( doseValue.volume.max ) );
                    if( volumeMinValue.formatUnits() !== volumeMaxValue.formatUnits() ) {
                        // If the units between min and max don't match, show both
                        volumeHtml += mw.calculators.getValueString( volumeMinValue );
                    } else {
                        volumeHtml += mw.calculators.getValueNumber( volumeMinValue );
                    }
                    volumeHtml += dash;
                    volumeHtml += mw.calculators.getValueString( doseValue.volume.max );
                }
                if( volumeHtml ) {
                    if( administration && ! administrationDisplayed ) {
                        volumeHtml += ' ' + administration;
                        administrationDisplayed = true;
                    }
                    volumeHtml = $( '<li>' ).append( volumeHtml );
                    $doseList.append( volumeHtml );
                    hasVolume = true;
                }
                $doseData.append( $doseList );
            }
            $dose.append( $doseData );
        }
        // Options column
        var $options = $( '<div>', {
            class: 'col-4 calculator-DrugDosageCalculator-options-cell'
        } );
        var indications = this.drug.getIndications();
        if( indications.length ) {
            $options.append( mw.calculators.getVariable( this.getVariableIds().indication ).createInput({
                class: 'calculator-container-input-DrugDosageCalculator-options',
                hideLabelMobile: true,
                inline: true
            } ) );
        }
        var routes = this.drug.getRoutes();
        if( routes.length ) {
            $options.append( mw.calculators.getVariable( this.getVariableIds().route  ).createInput({
                class: 'calculator-container-input-DrugDosageCalculator-options',
                hideLabelMobile: true,
                inline: true
            } ) );
        }
        // Don't show preparations if there isn't a dose with volume
        if( hasVolume ) {
            var preparations = this.drug.getPreparations();
            if( preparations.length ) {
                $options.append( mw.calculators.getVariable( this.getVariableIds().preparation  ).createInput({
                    class: 'calculator-container-input-DrugDosageCalculator-options',
                    hideLabelMobile: true,
                    inline: true
                } ) );
            }
        }
        $calculationContainer
            .append( $( '<div>', {
                    class: 'col-12 border'
                } ).append(
                    $drugLabel,
                    $( '<div>', {
                        class: 'row calculator-DrugDosageCalculator-dosage-row'
                    } )
                        .append(
                            $dose,
                            $options
                        )
                )
            );
        return;
        var calculation = this;
        $calculationContainer.each( function() {
            $( this ).empty();
            var $infoButton = null;
            if( this.hasInfo() ) {
                $infoButton = $( '<a>', {
                    'data-toggle': 'collapse',
                    href: '#' + this.getContainerClass() + '-info',
                    role: 'button',
                    'aria-expanded': 'false',
                    'aria-controls': this.getContainerClass() + '-info'
                } )
                    .append( $( '<i>', {
                        class: 'far fa-question-circle'
                    } ) );
                $label
                    .append( $( '<span>', {
                            class: 'calculator-calculation-column-label-info'
                        } )
                            .append( $infoButton )
                    );
            }
            if( calculation.hasInfo() ) {
                var infoHtml = '';
                if( calculation.description ) {
                    infoHtml += $( '<p>', {
                        html: calculation.description
                    } )[ 0 ].outerHTML;
                }
                if( calculation.formula ) {
                    infoHtml += $( '<span>', {
                        class: calculation.getContainerClass() + '-formula'
                    } )[ 0 ].outerHTML;
                    var api = new mw.Api();
                    api.parse( calculation.formula ).then( function( result ) {
                        $( '.' + calculation.getContainerClass() + '-formula' ).html( result );
                    } );
                }
                if( calculation.references.length ) {
                    var $references = $( '<ol>' );
                    for( var iReference in calculation.references ) {
                        $references.append( $( '<li>', {
                            text: calculation.references[ iReference ]
                        } ) );
                    }
                    infoHtml += $references[ 0 ].outerHTML;
                }
                var infoContainerId = calculation.getContainerClass() + '-info';
                var $infoContainer = $( '#' + infoContainerId );
                if( $infoContainer.length ) {
                    $infoContainer.empty();
                }
                $infoContainer = $( '<tr>', {
                    id: infoContainerId,
                    class: 'collapse'
                } )
                    .append( $( '<td>', {
                        colspan: 2
                    } ).append( infoHtml ) );
                $( this ).after( $infoContainer );
            }
        } );
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getCalculationData = function() {
        var inputData = new mw.calculators.objectClasses.CalculationData();
        // Add variables created by this calculation
        var variableIds = this.getVariableIds();
        for( var variableType in variableIds ) {
            inputData.variables.optional.push( variableIds[ variableType ] );
        }
        var dataTypes = inputData.getDataTypes();
        // Data is only actually required if it is required by every dosage for the drug.
        // Data marked as required by an individual dosage that does not appear in every
        // dosage will be converted to optional.
        var requiredInputData = new mw.calculators.objectClasses.CalculationData();
        // Need a way to tell the first iteration of the loop to initialize the required variables to a value that
        // is distinct from the empty array (populated across loop using array intersect, so could become [] and shouldn't
        // reinitialize).
        var initializeRequiredData = true;
        // Iterate through each dosage to determine variable dependency
        for( var iDosage in this.drug.dosages ) {
            var dosageInputData = this.drug.dosages[ iDosage ].getCalculationData();
            inputData = inputData.merge( dosageInputData );
            for( var iDataType in dataTypes ) {
                var dataType = dataTypes[ iDataType ];
                if( initializeRequiredData ) {
                    requiredInputData[ dataType ].required = inputData[ dataType ].required;
                } else {
                    // Data is only truly required if it is required by all dosage calculations, so use array intersection
                    requiredInputData[ dataType ].required = requiredInputData[ dataType ].required.filter( function( index ) {
                        return dosageInputData[ dataType ].required.indexOf( index ) !== -1;
                    } );
                }
            }
            initializeRequiredData = false;
        }
        for( var iDataType in dataTypes ) {
            var dataType = dataTypes[ iDataType ];
            // Move any data marked required in inputData to optional if it not actually required (i.e. doesn't appear
            // in requiredInputData).
            inputData[ dataType ].optional = inputData[ dataType ].optional.concat( inputData[ dataType ].required.filter( function( index ) {
                return requiredInputData[ dataType ].required.indexOf( index ) === -1;
            } ) ).filter( mw.calculators.uniqueValues );
            inputData[ dataType ].required = requiredInputData[ dataType ].required;
        }
        return inputData;
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getCalculationDataValues = function() {
        var data = mw.calculators.objectClasses.AbstractCalculation.prototype.getCalculationDataValues.call( this );
        data.drug = this.drug;
        data.indication = data[ this.getVariablePrefix() + 'indication' ] !== null ?
            mw.calculators.getDrugIndication( mw.calculators.getVariable( this.getVariableIds().indication ).getValue() ) :
            null;
        delete data[ this.getVariablePrefix() + 'indication' ];
        data.preparation = data[ this.getVariablePrefix() + 'preparation' ] !== null ?
            this.drug.preparations[ mw.calculators.getVariable( this.getVariableIds().preparation ).getValue() ] :
            null;
        delete data[ this.getVariablePrefix() + 'preparation' ];
        data.route = data[ this.getVariablePrefix() + 'route' ] !== null ?
            mw.calculators.getDrugRoute( mw.calculators.getVariable( this.getVariableIds().route ).getValue() ) :
            null;
        delete data[ this.getVariablePrefix() + 'route' ];
        return data;
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getLabelHtml = function() {
        var $label = $( '<a>', {
            class: 'calculator-DrugDosageCalculator-drug-name',
            href: mw.util.getUrl( this.drug.name ),
            text: this.drug.name
        } ).css( 'background-color', '#fff' );
        var highlightColor = this.drug.color.getHighlightColor();
        if( highlightColor ) {
            var highlightContainerAttributes = {
                class: 'calculator-DrugDosageCalculator-drug-highlight'
            };
            var highlightContainerCss = {};
            highlightContainerCss[ 'background' ] = highlightColor;
            $label = $( '<span>', highlightContainerAttributes ).append( $label ).css( highlightContainerCss );
        }
        var primaryColor = this.drug.color.getPrimaryColor();
        if( primaryColor ) {
            var backgroundContainerAttributes = {
                class: 'calculator-DrugDosageCalculator-drug-background'
            };
            var backgroundContainerCss = {};
            if( this.drug.color.isStriped() ) {
                backgroundContainerCss[ 'background' ] = 'repeating-linear-gradient(135deg,rgba(0,0,0,0),rgba(0,0,0,0)10px,rgba(255,255,255,1)10px,rgba(255,255,255,1)20px),' + primaryColor;
            } else {
                backgroundContainerCss[ 'background'] = primaryColor;
            }
            $label = $( '<span>', backgroundContainerAttributes ).append( $label ).css( backgroundContainerCss );
        }
        return $label;
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getProperties = function() {
        var inheritedProperties = mw.calculators.objectClasses.AbstractCalculation.prototype.getProperties();
        return this.mergeProperties( inheritedProperties, {
            required: [
                'drug'
            ],
            optional: []
        } );
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getVariableIds = function() {
        return {
            indication: this.getVariablePrefix() + 'indication',
            preparation: this.getVariablePrefix() + 'preparation',
            route: this.getVariablePrefix() + 'route'
        };
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getVariableOptions = function( variableId ) {
        if( variableId === this.getVariablePrefix() + 'indication' ) {
            return this.drug.getIndications();
        } else if( variableId === this.getVariablePrefix() + 'preparation' ) {
            // Exclude preparations which require dilution
            return this.drug.getPreparations( true );
        } else if( variableId === this.getVariablePrefix() + 'route' ) {
            return this.drug.getRoutes();
        }
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.getVariablePrefix = function() {
        return this.drug.id + '-';
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.initialize = function() {
        if( typeof this.drug === 'string' ) {
            var drug = mw.calculators.getDrug( this.drug );
            if( !drug ) {
                throw new Error( 'DrugDosage references drug "' + this.drug + '" which is not defined' );
            }
            this.drug = drug;
        }
        this.updateVariables();
        mw.calculators.objectClasses.AbstractCalculation.prototype.initialize.call( this );
    };
    mw.calculators.objectClasses.DrugDosageCalculation.prototype.updateVariables = function() {
        var variableIds = this.getVariableIds();
        for( var variableType in variableIds ) {
            var variableId = variableIds[ variableType ];
            var variableOptions = this.getVariableOptions( variableId );
            var variableOptionValues = {};
            var defaultOption = 0;
            for( var iVariableOption in variableOptions ) {
                var variableOption = variableOptions[ iVariableOption ];
                defaultOption = variableOption.default ? iVariableOption : defaultOption;
                variableOptionValues[ variableOption.id ] = String( variableOption );
            }
            var defaultValue = variableOptions.length ? variableOptions[ defaultOption ].id : null;
            var variable = mw.calculators.getVariable( variableId );
            if( !variable ) {
                var newVariable = {};
                newVariable[ variableId ] = {
                    name: variableType.charAt(0).toUpperCase() + variableType.slice(1),
                    type: 'string',
                    defaultValue: defaultValue,
                    options: variableOptionValues
                };
                mw.calculators.addVariables( newVariable );
            } else {
                // Probably not ideal to reach into the variable to change these things directly
                // Perhaps add helper functions to variable class
                mw.calculators.variables[ variableId ].defaultValue = defaultValue;
                mw.calculators.variables[ variableId ].options = variableOptionValues;
            }
        }
    };
    mw.calculators.addDrugCalculators = function( moduleId, drugCalculatorData, className ) {
        className = className ? className : 'DrugDosageCalculator';
        for( var drugCalculatorId in drugCalculatorData ) {
            drugCalculatorData[ drugCalculatorId ].module = moduleId;
            for( var iCalculation in drugCalculatorData[ drugCalculatorId].calculations ) {
                drugCalculatorData[ drugCalculatorId].calculations[ iCalculation ] = moduleId + '-' +
                    drugCalculatorData[ drugCalculatorId].calculations[ iCalculation ];
            }
        }
        mw.calculators.addCalculators( moduleId, drugCalculatorData, className );
    };
    /**
     * Class DrugDosageCalculator
     * @param {Object} propertyValues
     * @returns {mw.calculators.objectClasses.DrugDosageCalculator}
     * @constructor
     */
    mw.calculators.objectClasses.DrugDosageCalculator = function( propertyValues ) {
        mw.calculators.objectClasses.CalculatorObject.call( this, this.getProperties(), propertyValues );
    };
    mw.calculators.objectClasses.DrugDosageCalculator.prototype = Object.create( mw.calculators.objectClasses.AbstractCalculator.prototype );
    mw.calculators.objectClasses.DrugDosageCalculator.prototype.doRender = function() {
        var $calculatorContainer = $( '.' + this.getContainerClass() );
        if( !$calculatorContainer.length ) {
            return;
        }
        $calculatorContainer.addClass( this.getCalculatorClass() );
        $calculatorContainer.empty();
        $calculatorContainer.append( $( '<h4>', {
            text: this.name
        } ) );
        var $calculationsContainer = $( '<div>', {
            class: 'container-fluid'
        } );
        $calculatorContainer.append( $calculationsContainer );
        for( var iCalculationId in this.calculations ) {
            var calculation = mw.calculators.getCalculation( this.calculations[ iCalculationId ] );
            var calculationContainerClass = 'row no-gutters ' + calculation.getContainerClass();
            var $calculationContainer = $( '<div>', {
                class: calculationContainerClass
            } );
            $calculationsContainer.append( $calculationContainer );
            calculation.render();
        }
    };
    mw.calculators.objectClasses.DrugDosageCalculator.prototype.getCalculatorClass = function() {
        return 'calculator-DrugDosageCalculator';
    };
    mw.calculators.objectClasses.DrugDosageCalculator.prototype.getProperties = function() {
        var inheritedProperties = mw.calculators.objectClasses.AbstractCalculator.prototype.getProperties();
        return this.mergeProperties( inheritedProperties, {
            required: [],
            optional: []
        } );
    };
}() );