Difference between revisions of "Propofol"

Propofol
Trade names	Diprivan
	Clinical data
Drug class	Sedative hypnotic
Uses	Induction and maintenance of anesthesia, sedation
Contraindications	Egg/soy allergy (controversial)
Routes of administration	Intravenous
Dosage	Induction of anesthesia: Adult: 1-2.5 mg/kg; Elderly: 1-1.5 mg/kg; Pediatric: 2.5-3.5 mg/kg; Maintenance of anesthesia: Adult: 100-200 mcg/kg/min; Elderly: 50-100 mcg/kg/min; Pediatric: 125-300 mcg/kg/min;
	Pharmacodynamics
Mechanism of action	GABA agonism
Adverse effects	Hypotension Bradycardia Pain on injection
	Pharmacokinetics
Onset of action	15-30 seconds
Duration of action	5-10 minutes
Metabolism	Liver glucuronidation
Redistribution half-life	2-8 minutes (initial) 30-70 minutes (slow)
Elimination half-life	1.5-31 hours
Clearance	1.5-2.2 L/min
Protein binding	95-99%
pKa	11
Volume of distribution	6-40 L (central) 150-700 L (steady state)
	Physical and chemical data
Formula	C12H18O
Molar mass	178.275 g/mol
	Article information
Editor rating	Unrated
Likes	0
	Top authors
	Chris Rishel, Barrett Larson and Test User 6

Revision as of 02:58, 17 March 2022

Provide a brief summary of this drug here. Test. Another test. Yet another test. Woooooo

@@ Line 33: / Line 33: @@
 | formula = C<sub>12</sub>H<sub>18</sub>O
 | molar_mass = 178.275 g/mol
-}}Provide a brief summary of this drug here. Test. Another test. Yet another test. Wooooo
+}}Provide a brief summary of this drug here. Test. Another test. Yet another test. Woooooo
 ==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==